MEP1B and TSPAN8

Number of citations of the paper that reports this interaction (PubMedID 27180358)
0

Data Source:
BioGRID (biochemical, two hybrid, affinity chromatography technology)

		MEP1B	TSPAN8
Description		meprin A subunit beta	tetraspanin 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex	Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Integrin Binding Protein Binding
	Biological Process	Proteolysis Inflammatory Response	Spermatogenesis Regulation Of Gene Expression Negative Regulation Of Blood Coagulation
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	Asthma ( 34103634 32296059) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Medication use (adrenergics, inhalants) ( 31015401) Monobrow ( 27182965) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Type 2 diabetes ( 30054458 32499647 30297969 18372903 29358691 28869590 22885922 20581827) Upper eyelid sagging severity ( 24869959)
Interacting Genes		13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8	6 interacting genes: MEP1B PNLIPRP1 PTCH1 SLC38A7 STX2 TIMM23
Entrez ID		4225	7103
HPRD ID		02667	02865
Ensembl ID		ENSG00000141434	ENSG00000127324
Uniprot IDs		J3QKX5 Q16820	P19075
PDB IDs		4GWM 4GWN 7AQ1 7AUW
Enriched GO Terms of Interacting Partners?		Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation	Meprin A Complex Response To Chlorate Neural Plate Axis Specification Hedgehog Family Protein Binding Hedgehog Receptor Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Asparagine Transport L-asparagine Transmembrane Transporter Activity
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