PYY and NPY5R

Number of citations of the paper that reports this interaction (PubMedID 12665544)
0

Data Source:
HPRD (in vivo)

		PYY	NPY5R
Description		peptide YY	neuropeptide Y receptor Y5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Neuron Projection Presynapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation	Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Signaling Negative Regulation Of Synaptic Transmission, GABAergic Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Generation Of Ovulation Cycle Rhythm Positive Regulation Of ERK1 And ERK2 Cascade Synaptic Signaling Via Neuropeptide
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Peptide YY (3-36)
Diseases
GWAS		Blood protein levels ( 30072576) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Pulse pressure ( 28135244) Response to taxane treatment (paclitaxel) ( 23006423) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA	4 interacting genes: NPY NUPR1 PYY RNF181
Entrez ID		5697	4889
HPRD ID		02869	03591
Ensembl ID		ENSG00000131096	ENSG00000164129
Uniprot IDs		P10082	Q15761
PDB IDs		2DEZ 2DF0 2L60 2NA5 7RT9 7YON
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Binding Outflow Tract Morphogenesis G Protein-coupled Receptor Activity Synaptic Signaling Via Neuropeptide Cardiac Left Ventricle Morphogenesis Signaling Cell Communication Cardiac Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Neuron Projection Regulation Of Amine Transport Feeding Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Generation Of Ovulation Cycle Rhythm Meprin A Complex TRC Complex Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission, GABAergic BAT3 Complex Binding Negative Regulation Of Secretion Negative Regulation Of Glutamate Secretion Locomotory Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of ERAD Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Presynapse Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Membrane Positive Regulation Of Catecholamine Secretion Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Amino Acid Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Tail-anchored Membrane Protein Insertion Into ER Membrane Plasma Membrane Synaptic Signaling Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Nitric Oxide Mediated Signal Transduction	Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Short-day Photoperiodism Hormone Activity Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Regulation Of Female Gonad Development Regulation Of Eating Behavior Monocyte Activation Negative Regulation Of Acute Inflammatory Response Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Adult Feeding Behavior Positive Regulation Of Feeding Behavior Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Autophagosome Assembly Fibroblast Apoptotic Process Regulation Of Type B Pancreatic Cell Proliferation Acetyltransferase Activator Activity Positive Regulation Of Cellular Respiration Epithelial Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Inflammatory Response Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Regulation Of Dopamine Metabolic Process Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Glycolytic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Oxidative Phosphorylation Neuronal Dense Core Vesicle Regulation Of Appetite Negative Regulation Of ATP Metabolic Process Photoperiodism Regulation Of Feeding Behavior Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Aerobic Respiration Positive Regulation Of Behavior
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