PYY and NPY2R

Number of citations of the paper that reports this interaction (PMID 11408607)
9

Data Source:
HPRD (in vitro)

		PYY	NPY2R
Gene Name		peptide YY	neuropeptide Y receptor Y2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Nonmotile Primary Cilium
	Molecular Function	G-protein Coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding	Peptide YY Receptor Activity Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Digestion Feeding Behavior Cell Proliferation Regulation Of Appetite Eating Behavior	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Locomotory Behavior Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Neurological System Process Positive Regulation Of Dopamine Secretion Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Secretion Negative Regulation Of Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		5 interactors: MEP1B NPY1R NPY2R NPY4R NPY5R	3 interactors: NPY PYY RGS12
Entrez ID		5697	4887
HPRD ID		02869	01216
Ensembl ID		ENSG00000131096	ENSG00000185149
Uniprot IDs		P10082	P49146
PDB IDs		2DEZ 2DF0 2L60	2IK3
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Outflow Tract Morphogenesis Feeding Behavior Synaptic Transmission Behavior Cardiac Left Ventricle Morphogenesis Heart Morphogenesis Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cardiac Ventricle Morphogenesis Heart Development Cardiac Ventricle Development Generation Of Ovulation Cycle Rhythm Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Anion Transport Cardiac Chamber Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cardiovascular System Development Negative Regulation Of Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Organ Morphogenesis Locomotory Behavior Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of Glutamate Secretion Cell Surface Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Blood Circulation Regulation Of Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Catecholamine Secretion Regulation Of Glutamate Secretion Negative Regulation Of Transport Negative Regulation Of Membrane Potential Regulation Of Feeding Behavior Negative Regulation Of Neurological System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Nitric Oxide Mediated Signal Transduction Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Dopamine Secretion Response To Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Smooth Muscle Contraction Negative Regulation Of CAMP Biosynthetic Process	Regulation Of Appetite Neuropeptide Signaling Pathway Feeding Behavior Digestion Positive Regulation Of Appetite Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Behavior Regulation Of Response To Food Cell Proliferation Eating Behavior Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction
Tagcloud ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	adaptations anticonvulsive bdnf conducting decades differing ecs ect egr1 electroconvulsive fos inverse neuritin neuropeptides npy1r npy5r nrn points psd95 quantities seizures snap29 syn synapsin synaptotagmin syt transitory underline
Tagcloud (Difference) ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	adaptations anticonvulsive bdnf conducting decades differing ecs ect egr1 electroconvulsive fos inverse neuritin neuropeptides npy1r npy5r nrn points psd95 quantities seizures snap29 syn synapsin synaptotagmin syt transitory underline
Tagcloud (Intersection) ?