PYY and NPY2R

Number of citations: 0 (PubMedID 11408607)
Data Source: HPRD (in vitro)

		PYY	NPY2R
Name		peptide YY	neuropeptide Y receptor Y2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cilium Membrane Non-motile Cilium Presynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding Signaling Receptor Activity
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Locomotory Behavior Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Nervous System Process Positive Regulation Of Dopamine Secretion Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Negative Regulation Of Secretion Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Synaptic Signaling Via Neuropeptide Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		None	Cysteamine Peptide YY (3-36) Obinepitide
GWAS		Blood protein levels ( 30072576 ) Diverticular disease ( 30177863 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL levels x fish oil supplementation interaction (2df) ( 33760818 ) Pulse pressure ( 28135244 ) Response to taxane treatment (paclitaxel) ( 23006423 ) Triglyceride levels ( 32203549 )	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Premature menopause in childhood cancer survivors ( 29432556 )
Interacting Genes		6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA	4 interacting genes: NPY PYY RGS12 TRARG1
Entrez ID		5697	4887
HPRD ID		02869	01216
Ensembl ID		ENSG00000131096	ENSG00000185149
Uniprot IDs		P10082	P49146
PDB IDs		2DEZ 2DF0 2L60 2NA5 7RT9 7YON	7X9B 7YON 7YOO 8K6N
GO Terms Enriched among Interactors		Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Binding Outflow Tract Morphogenesis G Protein-coupled Receptor Activity Synaptic Signaling Via Neuropeptide Cardiac Left Ventricle Morphogenesis Signaling Cell Communication Cardiac Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Neuron Projection Regulation Of Amine Transport Feeding Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Generation Of Ovulation Cycle Rhythm Meprin A Complex TRC Complex Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission, GABAergic BAT3 Complex Binding Negative Regulation Of Secretion Negative Regulation Of Glutamate Secretion Locomotory Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of ERAD Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Presynapse Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Membrane Positive Regulation Of Catecholamine Secretion Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Amino Acid Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Tail-anchored Membrane Protein Insertion Into ER Membrane Plasma Membrane Synaptic Signaling Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Nitric Oxide Mediated Signal Transduction	Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Short-day Photoperiodism Hormone Activity G Protein-coupled Receptor Signaling Pathway Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Antifungal Humoral Response Adult Feeding Behavior Positive Regulation Of Feeding Behavior Vesicle Fusion To Plasma Membrane Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Epithelial Cell Differentiation Endosome To Plasma Membrane Protein Transport Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food D-glucose Import Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Feeding Behavior GTPase Regulator Activity Photoperiodism D-glucose Transmembrane Transport Positive Regulation Of Behavior Negative Regulation Of Inflammatory Response To Antigenic Stimulus Hexose Transmembrane Transport Regulation Of Response To Nutrient Levels Terminal Bouton Perinuclear Region Of Cytoplasm Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development Negative Regulation Of Blood Pressure Regulation Of Acute Inflammatory Response Carbohydrate Transmembrane Transport