GRP and MEP1B

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		GRP	MEP1B
Description		gastrin releasing peptide	meprin A subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Mast Cell Degranulation Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Behavioral Fear Response	Proteolysis Inflammatory Response
Pathways		Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreas volume ( 34128465) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Venous thromboembolism ( 32232851)	Metabolite levels ( 23823483) TRAIL levels ( 27989323)
Interacting Genes		5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B	13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8
Entrez ID		2922	4225
HPRD ID		08845	02667
Ensembl ID		ENSG00000134443	ENSG00000141434
Uniprot IDs		A0A140VJM7 P07492	J3QKX5 Q16820
PDB IDs		2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H 7W3Z 8H0Q	4GWM 4GWN 7AQ1 7AUW
Enriched GO Terms of Interacting Partners?		Meprin A Complex Psychomotor Behavior Motor Behavior Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Glucagon Processing Metalloendopeptidase Activity Epidermal Growth Factor Receptor Ligand Maturation Metallopeptidase Activity Hormone Metabolic Process Protein Processing Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Neutrophil Chemotaxis Intercellular Canaliculus Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Positive Regulation Of Behavioral Fear Response Mesenchymal Cell Development Positive Regulation Of Fear Response Metallodipeptidase Activity Protein Maturation Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Cell-cell Adhesion Mediated By Integrin Dipeptidyl-peptidase Activity Virion Attachment To Host Cell Proteolysis Regulation Of Behavioral Fear Response Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Neuropeptide Receptor Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Hydrolase Activity Chemorepellent Activity Regulation Of Respiratory Gaseous Exchange Neuropeptide Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Behavior	Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation
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