GRP and MEP1A

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		GRP	MEP1A
Description		gastrin releasing peptide	meprin A subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Mast Cell Degranulation Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Behavioral Fear Response	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing
Pathways		Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreas volume ( 34128465) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Venous thromboembolism ( 32232851)
Interacting Genes		5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		2922	4224
HPRD ID		08845	02666
Ensembl ID		ENSG00000134443	ENSG00000112818
Uniprot IDs		A0A140VJM7 P07492	B7ZL91 Q16819
PDB IDs		2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H 7W3Z 8H0Q	7UAB 7UAC 7UAE 7UAF 7UAI
Enriched GO Terms of Interacting Partners?		Meprin A Complex Psychomotor Behavior Motor Behavior Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Glucagon Processing Metalloendopeptidase Activity Epidermal Growth Factor Receptor Ligand Maturation Metallopeptidase Activity Hormone Metabolic Process Protein Processing Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Neutrophil Chemotaxis Intercellular Canaliculus Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Positive Regulation Of Behavioral Fear Response Mesenchymal Cell Development Positive Regulation Of Fear Response Metallodipeptidase Activity Protein Maturation Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Cell-cell Adhesion Mediated By Integrin Dipeptidyl-peptidase Activity Virion Attachment To Host Cell Proteolysis Regulation Of Behavioral Fear Response Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Neuropeptide Receptor Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Hydrolase Activity Chemorepellent Activity Regulation Of Respiratory Gaseous Exchange Neuropeptide Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Behavior	Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen
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