PDE4C and OSGIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDE4C	OSGIN1
Description		phosphodiesterase 4C	oxidative stress induced growth inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cilium Cell Projection	Midbody
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Monooxygenase Activity Protein Binding Growth Factor Activity Oxidoreductase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		A body shape index ( 34021172) Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		9 interacting genes: DDIT4L GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A	47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4
Entrez ID		5143	29948
HPRD ID		02529	06412
Ensembl ID		ENSG00000105650	ENSG00000140961
Uniprot IDs		O43849 P78505 Q08493 Q32MM7 Q7KYS4	Q9UJX0
PDB IDs		2QYM
Enriched GO Terms of Interacting Partners?		Somite Specification Segment Specification HMG Box Domain Binding Somite Development Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Embryonic Pattern Specification Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Response To Metformin Negative Regulation Of Leukocyte Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Natural Killer Cell Chemotaxis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Sclerotome Development Regulation Of Cell Migration Habenula Development Pallium Development Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Motility Chromatin Regulation Of Locomotion Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Binding DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process Nervous System Development Activation-induced Cell Death Of T Cells Identical Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Developmental Process Response To Nitrosative Stress Positive Regulation Of Proteolysis CAMP Catabolic Process Regulation Of Cell Communication Regulation Of Signaling System Development Regulation Of Cell Population Proliferation Anoikis HMG Box Domain Binding Nucleus Embryonic Pattern Specification Cyclic Nucleotide Catabolic Process Myelin Maintenance Nucleoplasm Positive Regulation Of Intracellular Signal Transduction Segment Specification
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