PDE4C and ZNF280A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDE4C	ZNF280A
Description		phosphodiesterase 4C	zinc finger protein 280A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cilium Cell Projection	Nucleus
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	CAMP Catabolic Process Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		A body shape index ( 34021172) Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: DDIT4L GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A	8 interacting genes: CABP5 CALM1 CALM2 CALM3 EIF1AD ENOPH1 KDM1A PDE4C
Entrez ID		5143	129025
HPRD ID		02529	18129
Ensembl ID		ENSG00000105650	ENSG00000169548
Uniprot IDs		O43849 P78505 Q08493 Q32MM7 Q7KYS4	A0A0G2JN84 P59817
PDB IDs		2QYM
Enriched GO Terms of Interacting Partners?		Somite Specification Segment Specification HMG Box Domain Binding Somite Development Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Embryonic Pattern Specification Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Response To Metformin Negative Regulation Of Leukocyte Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Natural Killer Cell Chemotaxis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pattern Specification Process Sclerotome Development Regulation Of Cell Migration Habenula Development Pallium Development Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Motility Chromatin Regulation Of Locomotion Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Calcium Channel Regulator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Cell Cycle G2/M Phase Transition Neural Nucleus Development Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Voltage-gated Potassium Channel Complex Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cytokinesis Vesicle-mediated Transport In Synapse Regulation Of Calcium-mediated Signaling Regulation Of Striated Muscle Contraction
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