TRAF7 and RIPK4

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TRAF7	RIPK4
Gene Name		TNF receptor-associated factor 7, E3 ubiquitin protein ligase	receptor-interacting serine-threonine kinase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Transcription, DNA-templated Apoptotic Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Protein Sumoylation Positive Regulation Of MAPK Cascade Cellular Response To Interleukin-6 Positive Regulation Of Apoptotic Signaling Pathway	Morphogenesis Of An Epithelium Protein Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CYLD MAP3K3 RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	7 interactors: BIRC2 BIRC3 PRKCB PRKCD RHOA TRAF7 XIAP
Entrez ID		84231	54101
HPRD ID		06977	10419
Ensembl ID		ENSG00000131653	ENSG00000183421
Uniprot IDs		B3KQY7 Q6Q0C0	Q96T11 Q9H4D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Positive Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Catabolic Process Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Immune Response Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Modification Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Negative Regulation Of Necrotic Cell Death Positive Regulation Of Protein Ubiquitination Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune System Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Positive Regulation Of Immune Response Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Necroptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Catalytic Activity Cellular Protein Modification Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Peptidase Activity Response To Stress
Tagcloud ?		adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?