TRAF7 and CYLD

Number of citations of the paper that reports this interaction (PMID 16230348)
36

Data Source:
HPRD (in vivo)

		TRAF7	CYLD
Gene Name		TNF receptor-associated factor 7, E3 ubiquitin protein ligase	cylindromatosis (turban tumor syndrome)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Structural Constituent Of Ribosome Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Transcription, DNA-templated Apoptotic Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Protein Sumoylation Positive Regulation Of MAPK Cascade Cellular Response To Interleukin-6 Positive Regulation Of Apoptotic Signaling Pathway	Cytoplasmic Translation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of NF-kappaB Import Into Nucleus Innate Immune Response Negative Regulation Of T Cell Differentiation Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Cilium Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Crohn's disease ( 22412388) Leprosy ( 22019778)
Protein-Protein Interactions		10 interactors: CYLD MAP3K3 RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	15 interactors: AKT1 AURKB DDX58 HDAC6 IKBKG ITCH MAPRE1 OPTN PPP2R4 TRAF2 TRAF6 TRAF7 TRAIP TUBA1A UBE2S
Entrez ID		84231	1540
HPRD ID		06977	05427
Ensembl ID		ENSG00000131653	ENSG00000083799
Uniprot IDs		B3KQY7 Q6Q0C0	Q9NQC7
PDB IDs			1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Positive Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Catabolic Process Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Immune Response Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Polyubiquitination Cell Death Death Regulation Of Cell Death Positive Regulation Of Innate Immune Response Mitotic Cell Cycle Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Catabolic Process Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death NIK/NF-kappaB Signaling Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of JNK Cascade Cellular Protein Modification Process Protein K29-linked Ubiquitination Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Innate Immune Response Intracellular Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination	181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate
Tagcloud (Difference) ?		adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination	181b adjacent array assays blot coding colony corroboration deregulated downregulation luciferase micro micrornas mir mirnas mtt oncogenes papillary promoted putative qpcr reporter rnas specimens thyroid tpc1 untranslated utr validate
Tagcloud (Intersection) ?