HOXA11 and YY1

Number of citations: 0 (PubMedID 16963455)
Data Source: BioGRID (pull down, affinity chromatography technology)

		HOXA11	YY1
Name		homeobox A11	YY1 transcription factor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Chondrocyte Differentiation Chondrocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Prostate Gland Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Response To Testosterone Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Response To Estrogen Positive Regulation Of DNA-templated Transcription Cell Development Developmental Growth Uterus Development Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Chondrocyte Development	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Formation of the ureteric bud	Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Diseases		Radioulnar synostosis with amegakaryocytic thrombocytopenia	None
GWAS		A body shape index ( 34021172 ) Heel bone mineral density ( 30598549 28869591 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 25673412 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	Estimated glomerular filtration rate ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Pulse pressure ( 30224653 )
Interacting Genes		5 interacting genes: CREBBP GMNN MEIS1 PGBD3 YY1	98 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		3207	7528
HPRD ID		00846	02482
Ensembl ID		ENSG00000005073	ENSG00000100811
Uniprot IDs		P31270	P25490
PDB IDs		Not available	1UBD 1ZNM 4C5I
GO Terms Enriched among Interactors		Chromatin Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of DNA Metabolic Process Cellular Response To UV Anatomical Structure Morphogenesis Sequence-specific DNA Binding Animal Organ Morphogenesis Recombinational Repair Positive Regulation Of DNA Repair Histone H3K18 Acetyltransferase Activity Response To UV N-terminal Peptidyl-lysine Acetylation Cellular Response To Light Stimulus Double-strand Break Repair Via Homologous Recombination Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Immunoglobulin Heavy Chain V-D-J Recombination Response To Prostaglandin F Regulation Of DNA Replication DNA Replication Preinitiation Complex Assembly Cellular Response To Radiation Hemopoiesis MRF Binding Transcription Corepressor Activity Double-strand Break Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Chromatin Binding Chromatin Immunoglobulin V(D)J Recombination Positive Regulation Of DNA Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Peptidyl-lysine Acetylation Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Heat Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Response To Light Stimulus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Definitive Hemopoiesis Lens Morphogenesis In Camera-type Eye Regulation Of DNA Strand Elongation Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding	Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling