HOXA11 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		HOXA11	GMNN
Description		homeobox A11	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Chondrocyte Differentiation Chondrocyte Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Prostate Gland Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Response To Testosterone Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Response To Estrogen Positive Regulation Of DNA-templated Transcription Cell Development Developmental Growth Uterus Development Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Chondrocyte Development	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways		Formation of the ureteric bud	Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases		Radioulnar synostosis with amegakaryocytic thrombocytopenia
GWAS		A body shape index ( 34021172) Heel bone mineral density ( 30598549 28869591) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: CREBBP GMNN MEIS1 PGBD3 YY1	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3207	51053
HPRD ID		00846	06783
Ensembl ID		ENSG00000005073	ENSG00000112312
Uniprot IDs		P31270	O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		Chromatin Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of DNA Metabolic Process Cellular Response To UV Anatomical Structure Morphogenesis Sequence-specific DNA Binding Animal Organ Morphogenesis Recombinational Repair Positive Regulation Of DNA Repair Histone H3K18 Acetyltransferase Activity Response To UV N-terminal Peptidyl-lysine Acetylation Cellular Response To Light Stimulus Double-strand Break Repair Via Homologous Recombination Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Immunoglobulin Heavy Chain V-D-J Recombination Response To Prostaglandin F Regulation Of DNA Replication DNA Replication Preinitiation Complex Assembly Cellular Response To Radiation Hemopoiesis MRF Binding Transcription Corepressor Activity Double-strand Break Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Chromatin Binding Chromatin Immunoglobulin V(D)J Recombination Positive Regulation Of DNA Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Peptidyl-lysine Acetylation Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Heat Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase I Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Response To Light Stimulus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Definitive Hemopoiesis Lens Morphogenesis In Camera-type Eye Regulation Of DNA Strand Elongation Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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