TLX2 and GTF2A1L

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TLX2	GTF2A1L
Description		T cell leukemia homeobox 2	general transcription factor IIA subunit 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Animal Organ Development Negative Regulation Of Dendrite Morphogenesis	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription Cognition
Pathways
Drugs
Diseases
GWAS			Adult body size ( 32376654) Hepcidin/ferritin ratio ( 27846281) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128)
Interacting Genes		14 interacting genes: GTF2A1L HNF1B IRF6 IRF9 KRTAP6-2 MCM4 MEIS1 NFIC NFIX POU2F1 POU6F2 TLE1 YWHAH ZNF502	25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3
Entrez ID		3196	11036
HPRD ID		07254	05640
Ensembl ID		ENSG00000115297	ENSG00000242441
Uniprot IDs		O43763	Q9UNN4
PDB IDs		3A03
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Chromatin Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA Replication Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-templated Transcription Animal Organ Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Glucocorticoid Catabolic Process Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Hepatoblast Differentiation Regulation Of Pronephros Size Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Cerebellar Granule Cell To Purkinje Cell Synapse ISGF3 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic DNA Replication Initiation	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Kinase CK2 Complex System Development Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Transcription Factor TFIIA Complex DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cerebral Cortex Regionalization Regionalization RNA Polymerase II General Transcription Initiation Factor Binding Central Nervous System Development Nucleoplasm Anterior/posterior Pattern Specification RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Embryonic Skeletal System Morphogenesis
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