TLX2 and IRF6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TLX2	IRF6
Description		T cell leukemia homeobox 2	interferon regulatory factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Animal Organ Development Negative Regulation Of Dendrite Morphogenesis	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Keratinocyte Differentiation Skin Development Keratinocyte Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Stem Cell Proliferation Cranial Skeletal System Development Negative Regulation Of Stem Cell Proliferation
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS			Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734) Systolic blood pressure ( 30224653)
Interacting Genes		14 interacting genes: GTF2A1L HNF1B IRF6 IRF9 KRTAP6-2 MCM4 MEIS1 NFIC NFIX POU2F1 POU6F2 TLE1 YWHAH ZNF502	4 interacting genes: IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3196	3664
HPRD ID		07254	06227
Ensembl ID		ENSG00000115297	ENSG00000117595
Uniprot IDs		O43763	G0Z349 O14896
PDB IDs		3A03
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Chromatin Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA Replication Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-templated Transcription Animal Organ Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Glucocorticoid Catabolic Process Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Hepatoblast Differentiation Regulation Of Pronephros Size Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Cerebellar Granule Cell To Purkinje Cell Synapse ISGF3 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic DNA Replication Initiation	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Plasmacytoid Dendritic Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Development Type B Pancreatic Cell Maturation DNA Binding Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Ciliary Transition Fiber Pronucleus Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Morphogenesis Germinal Center B Cell Differentiation Kinetochore Assembly Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Negative Regulation Of RNA Metabolic Process Kinetochore Organization Regulation Of Metabolic Process Endocrine Pancreas Development
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