PSME3 and ITPKB

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSME3	ITPKB
Description		proteasome activator subunit 3	inositol-trisphosphate 3-kinase B
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Proteasome Activator Complex Membrane Ciliary Basal Body	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Membrane
	Molecular Function	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	Nucleotide Binding Inositol Hexakisphosphate Kinase Activity Protein Binding Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity
	Biological Process	Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	MAPK Cascade Myeloid Cell Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Differentiation Inositol Trisphosphate Metabolic Process Inositol Phosphate Biosynthetic Process Negative Regulation Of Neutrophil Apoptotic Process Common Myeloid Progenitor Cell Proliferation Positive Thymic T Cell Selection Thymic T Cell Selection Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Alpha-beta T Cell Differentiation Phosphatidylinositol Phosphate Biosynthetic Process Cellular Response To Calcium Ion
Pathways		Proteasome assembly	Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Dentures ( 31235808) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease ( 28892059 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		63 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CEBPA CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FMR1 FOXD4L1 FXR1 FXR2 GPATCH2L HSPA5 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PICK1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10	14 interacting genes: AKT1 CALM1 CEP70 CTDSP1 GOLGA2 IFT88 KRT34 PPP3CA PRKACA PRKCA PSME3 SCAI TRIM54 UBQLN2
Entrez ID		10197	3707
HPRD ID		05500	00942
Ensembl ID		ENSG00000131467	ENSG00000143772
Uniprot IDs		B3KQ25 P61289 V9HWJ8	B2R9J0 P27987
PDB IDs		7YQC 7YQD
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cellular Response To Staurosporine Response To Nutrient Levels Protein Binding Protein Domain Specific Binding Nucleus Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cellular Response To Nutrient Levels Macromolecule Catabolic Process Cytosol Positive Regulation Of Protein Metabolic Process Cellular Response To Alkaloid Post-translational Protein Modification Response To Xenobiotic Stimulus Neuron Projection Response To Alkaloid Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Leukocyte Apoptotic Process Response To UV Proteolysis Regulation Of Protein Metabolic Process Signal Transduction By P53 Class Mediator Mononuclear Cell Differentiation Protein-containing Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Translation Regulator Activity Cellular Response To Glucose Starvation Cellular Response To Actinomycin D Positive Regulation Of Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Developmental Process Modification-dependent Protein Catabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of RNA Metabolic Process Protein Destabilization Response To Actinomycin D HLH Domain Binding Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Stability Leukocyte Differentiation Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing Disordered Domain Specific Binding Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Angiotensin-activated Signaling Pathway Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cilium Regulation Of Vesicle-mediated Transport Proteasomal Protein Catabolic Process Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Muscle System Process Regulation Of Calcium-mediated Signaling Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Ciliary Basal Body Proteolysis Involved In Protein Catabolic Process Regulation Of Metal Ion Transport Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Transmembrane Transport Renal System Process Renal Sodium Ion Absorption Renal Sodium Ion Transport Regulation Of Protein Catabolic Process Response To Calcium Ion Regulation Of Autophagy Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Calcium Channel Complex Regulation Of Calcium Ion Transmembrane Transport Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Negative Regulation Of Transport Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cilium Assembly Regulation Of Nervous System Development Positive Regulation Of Steroid Biosynthetic Process Protein Kinase Binding Regulation Of Cell Cycle G1/S Phase Transition
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