MCM2 and CCNB2

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		MCM2	CCNB2
Gene Name		minichromosome maintenance complex component 2	cyclin B2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm Microtubule Cytoskeleton MCM Complex	Nucleoplasm Centrosome Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Protein Binding ATP Binding Histone Binding Metal Ion Binding	Protein Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Nucleosome Assembly Cell Cycle Cellular Response To Interleukin-4	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle In Utero Embryonic Development Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Growth T Cell Homeostasis Thymus Development Cell Division Regulation Of Cell Cycle
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Golgi Cisternae Pericentriolar Stack Reorganization Nuclear Pore Complex (NPC) Disassembly Nuclear Envelope Breakdown G2/M Transition Regulation of PLK1 Activity at G2/M Transition Cyclin B2 mediated events M Phase Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition Resolution of Sister Chromatid Cohesion Cell Cycle Checkpoints Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS			Metabolite levels ( 22916037)
Protein-Protein Interactions		47 interactors: AKAP8 APP ATM ATR CCNB2 CCNC CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL GNB5 GTF2B GTF2H1 HIST3H3 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHC2 PLK1 RAD52 RPA1 RPA2 RPA3 RPS4X TBP TCEA2 TERF1 TERF2IP	7 interactors: CDK1 CDK2 CDKN1A CKS1B CKS2 MCM2 TGFBR2
Entrez ID		4171	9133
HPRD ID		00303	04131
Ensembl ID		ENSG00000073111	ENSG00000157456
Uniprot IDs		P49736	O95067
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Mitotic Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle DNA-dependent DNA Replication DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Biosynthetic Process Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Metabolic Process DNA Recombinase Assembly Telomere Maintenance Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Division Cell Cycle Checkpoint Double-strand Break Repair Organelle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Regulation Of Phosphorylation Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Organ Regeneration Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Catalytic Activity Response To Drug DNA Damage Checkpoint Regulation Of Protein Import Into Nucleus, Translocation Mitotic Cell Cycle Checkpoint Cellular Response To Growth Factor Stimulus Response To Growth Factor Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Positive Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus DNA Replication Phosphorylation Positive Regulation Of Cell Cycle Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Peptidyl-threonine Phosphorylation Aging Centrosome Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Heart Growth Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cardiac Muscle Tissue Development Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle
Tagcloud ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	arap3 axillary bioinformatic chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions tgif2 top2a
Tagcloud (Difference) ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	arap3 axillary bioinformatic chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions tgif2 top2a
Tagcloud (Intersection) ?