MCM2 and RAD52

Number of citations of the paper that reports this interaction (PMID 15766559)
5

Data Source:
HPRD (in vitro, in vivo)

		MCM2	RAD52
Gene Name		minichromosome maintenance complex component 2	RAD52 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm Microtubule Cytoskeleton MCM Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Protein Binding ATP Binding Histone Binding Metal Ion Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Nucleosome Assembly Cell Cycle Cellular Response To Interleukin-4	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Lung cancer ( 22899653)
Protein-Protein Interactions		47 interactors: AKAP8 APP ATM ATR CCNB2 CCNC CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL GNB5 GTF2B GTF2H1 HIST3H3 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHC2 PLK1 RAD52 RPA1 RPA2 RPA3 RPS4X TBP TCEA2 TERF1 TERF2IP	12 interactors: ABL1 ERCC2 ERCC3 ERCC4 MCM2 MCM3 RAD51 RPA1 RPA2 SUMO1 UBE2I WRN
Entrez ID		4171	5893
HPRD ID		00303	11855
Ensembl ID		ENSG00000073111	ENSG00000002016
Uniprot IDs		P49736	F5GX32 P43351 Q3MI84 Q5DR82
PDB IDs			1H2I 1KN0
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Mitotic Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle DNA-dependent DNA Replication DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Biosynthetic Process Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Metabolic Process DNA Recombinase Assembly Telomere Maintenance Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Division Cell Cycle Checkpoint Double-strand Break Repair Organelle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	DNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding DNA Geometric Change DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Organelle Organization Cellular Response To Stress Chromosome Organization Nucleotide-excision Repair DNA Strand Elongation Involved In DNA Replication DNA Recombinase Assembly DNA Strand Elongation DNA Conformation Change DNA Replication Nucleotide-excision Repair, DNA Incision DNA Catabolic Process Cell Cycle Process Double-strand Break Repair UV Protection Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Mitotic Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Response To UV Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Response To Radiation Aromatic Compound Catabolic Process Mismatch Repair Base-excision Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Catabolic Process DNA Unwinding Involved In DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis
Tagcloud ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Difference) ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Intersection) ?