MCM2 and P2RX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MCM2	P2RX4
Description		minichromosome maintenance complex component 2	purinergic receptor P2X 4
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Nucleolus Cytoplasm Cytosol Cilium MCM Complex CMG Complex	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Monoatomic Ion Transport Response To Stress Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metal Ion Transport Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Cell Migration Positive Regulation Of Prostaglandin Secretion Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Regulation Of Ruffle Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection
Drugs			Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		57 interacting genes: AKAP8 APP ASF1A ATM ATR ATRIP CCNB2 CCNC CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB1 PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP UBE3A	9 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA WNT4
Entrez ID		4171	5025
HPRD ID		00303	09017
Ensembl ID		ENSG00000073111	ENSG00000135124
Uniprot IDs		P49736	Q99571
PDB IDs		4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7 7CIZ 7CJ0 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 8YJF 8YJM 9CAQ	9BQH 9BQI 9C48
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication DNA Replication Initiation Nucleic Acid Metabolic Process Nucleoplasm Chromosome, Telomeric Region Regulation Of DNA Replication Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Nucleus DNA Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair DNA Replication Origin Binding Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Cellular Response To Stress Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Chromosome Chromosome Organization Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Telomere Maintenance Response To Stress Mitotic Cell Cycle Phase Transition	Intermediate Filament Mitotic DNA Replication Initiation Positive Regulation Of Translational Elongation Nuclear Division Positive Regulation Of Ribosome Biogenesis Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Renal Vesicle Induction Nephron Morphogenesis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Dermatome Development Negative Regulation Of Male Gonad Development Renal Vesicle Formation Somatotropin Secreting Cell Differentiation Female Sex Determination Paramesonephric Duct Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Metanephric Nephron Development Keratin Filament Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Positive Regulation Of Cellular Component Biogenesis Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Pericyte Cell Differentiation Immature T Cell Proliferation In Thymus Blood Vessel Maturation Fibrinogen Binding Regulation Of Cortisol Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Testosterone Biosynthetic Process Histone Binding
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