MCM2 and RPS4X

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM2	RPS4X
Gene Name		minichromosome maintenance complex component 2	ribosomal protein S4, X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm Microtubule Cytoskeleton MCM Complex	Cytosol Ribosome Polysome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Protein Binding ATP Binding Histone Binding Metal Ion Binding	Structural Constituent Of Ribosome RRNA Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Nucleosome Assembly Cell Cycle Cellular Response To Interleukin-4	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Multicellular Organismal Development Positive Regulation Of Cell Proliferation Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Positive Regulation Of Translation
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AKAP8 APP ATM ATR CCNB2 CCNC CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL GNB5 GTF2B GTF2H1 HIST3H3 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHC2 PLK1 RAD52 RPA1 RPA2 RPA3 RPS4X TBP TCEA2 TERF1 TERF2IP	11 interactors: ARPC3 CAMK2D CTBP2 HNRNPH3 MCM2 RPS15 RPS5 RPS6 RPS7 RPS8 RPS9
Entrez ID		4171	6191
HPRD ID		00303	02427
Ensembl ID		ENSG00000073111
Uniprot IDs		P49736	B2R491 P62701
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Mitotic Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle DNA-dependent DNA Replication DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Biosynthetic Process Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Metabolic Process DNA Recombinase Assembly Telomere Maintenance Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Division Cell Cycle Checkpoint Double-strand Break Repair Organelle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	Viral Life Cycle Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Targeting To Membrane Translational Elongation RNA Catabolic Process Cellular Protein Complex Disassembly Protein Complex Disassembly Establishment Of Protein Localization To Membrane Translational Initiation MRNA Metabolic Process Viral Process Ribosomal Small Subunit Biogenesis Establishment Of Protein Localization To Organelle Protein Localization To Membrane Protein Targeting Aromatic Compound Catabolic Process Protein Localization To Organelle Translation Cytoplasmic Transport RRNA Processing RRNA Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Ribosome Biogenesis Intracellular Protein Transport Ribonucleoprotein Complex Biogenesis Ribosomal Small Subunit Assembly Cellular Protein Localization RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Protein Transport Establishment Of Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Biosynthetic Process Intracellular Transport Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Translational Fidelity Macromolecule Biosynthetic Process
Tagcloud ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rq scnt slc25a6 somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Difference) ?		1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed	aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rq scnt slc25a6 somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Intersection) ?