SUPT16H and CCT6A

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SUPT16H	CCT6A
Description		SPT16 homolog, facilitates chromatin remodeling subunit	chaperonin containing TCP1 subunit 6A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex FACT Complex	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding WD40-repeat Domain Binding ATP-dependent Protein Folding Chaperone
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of DNA-templated Transcription, Elongation	Protein Folding Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172) Macular telangiectasia type 2 ( 33654266) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Systolic blood pressure ( 30224653)
Interacting Genes		15 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A H3C1 H4C1 MCM3 MCM4 NEK9 PARP1 RNF10 SREK1 SRPK2 SUMO2 USP7	17 interacting genes: CEBPA DUX4 ERCC6 IMPA2 KDM5A LINC01554 MLX MYBPC2 OGT PARP4 PTEN SGCG SUMO2 SUMO4 SUPT16H TRIM31 TTN
Entrez ID		11198	908
HPRD ID		16088	00089
Ensembl ID		ENSG00000092201	ENSG00000146731
Uniprot IDs		Q9Y5B9	P40227
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL 8I17 8YJF 8YJM 9EH2	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Chromosome Chromosome, Telomeric Region Chromatin Remodeling Structural Constituent Of Chromatin Chromatin Organization Telomere Organization Nucleus Nucleosome Mitotic DNA Replication Initiation Regulation Of Establishment Of Protein Localization To Telomere Nucleoplasm Regulation Of Establishment Of Protein Localization To Chromosome RNA Binding DNA Binding CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Epigenetic Regulation Of Gene Expression Regulation Of Telomere Maintenance Nucleosome Assembly Single-stranded DNA Helicase Activity DNA Strand Elongation Nucleic Acid Metabolic Process Chromosome Organization Protein Heterodimerization Activity Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication Initiation Regulation Of Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Gene Expression, Epigenetic Protein-DNA Complex Assembly NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Macromolecule Metabolic Process NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein Localization To Chromatin DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process DNA Recombination	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Protein Tag Activity Positive Regulation Of Transcription By RNA Polymerase II Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation Factor Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Gene Expression M Band Circadian Rhythm Ubiquitin-like Protein Ligase Binding Negative Regulation Of Cell Cycle Regulation Of Peptidyl-serine Phosphorylation Regulation Of Proteolysis Protein Modification Process Sarcomere Organization Structural Constituent Of Muscle Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Macromolecule Metabolic Process Protein Sumoylation Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Nucleoplasm Inflammatory Response Response To Vitamin B2 C/EBP Complex Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Glycerol-2-phosphatase Activity
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