MCM3 and CDC6

Number of citations of the paper that reports this interaction (PMID 11046155)
259

Data Source:
BioGRID (affinity chromatography technology, biochemical, pull down)
HPRD (in vivo)

		MCM3	CDC6
Gene Name		minichromosome maintenance complex component 3	cell division cycle 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Centrosome Membrane MCM Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 RPA2 STAT1 SUPT16H SYF2 YWHAQ	36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1
Entrez ID		4172	990
HPRD ID		04072	04022
Ensembl ID		ENSG00000112118	ENSG00000094804
Uniprot IDs		B4DUQ9 B4DWW4 P25205	Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Cellular Response To Stress Chromosome Organization Cellular Metabolic Process DNA Repair Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition DNA Conformation Change DNA Damage Checkpoint Double-strand Break Repair Via Break-induced Replication Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process DNA Recombinase Assembly Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process
Tagcloud ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?		3k499a alanine archaeal atpases electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative sensor severely shaped subtly superfamily unwinding	antiserum cdc18p cdc6p cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting sbf schizosaccharomyces timed
Tagcloud (Intersection) ?		cerevisiae saccharomyces