MCM3 and MCM3AP

Number of citations of the paper that reports this interaction (PMID 12226073)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MCM3	MCM3AP
Gene Name		minichromosome maintenance complex component 3	minichromosome maintenance complex component 3 associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Centrosome Membrane MCM Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	DNA Binding Transferase Activity, Transferring Acyl Groups
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	Immune System Process DNA Replication Protein Import Into Nucleus MRNA Transport
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		31 interactors: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 RPA2 STAT1 SUPT16H SYF2 YWHAQ	19 interactors: APC CDC25A CDC42 CDC73 CLSTN1 CRMP1 ENY2 EP300 FAM118B MCM3 NUDT5 POLR2G RAC1 SMAD3 SMAD9 SUV39H2 TAF1D TMEM216 TSC22D1
Entrez ID		4172	8888
HPRD ID		04072	04483
Ensembl ID		ENSG00000112118	ENSG00000160294
Uniprot IDs		B4DUQ9 B4DWW4 P25205	O60318
PDB IDs			4DHX
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Cellular Response To Stress Chromosome Organization Cellular Metabolic Process DNA Repair Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition DNA Conformation Change DNA Damage Checkpoint Double-strand Break Repair Via Break-induced Replication Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process DNA Recombinase Assembly Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Stability Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell-cell Junction Organization Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Anatomical Structure Morphogenesis Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Cell Cycle DNA-templated Transcription, Elongation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Cycle Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of MRNA 3'-end Processing Response To Hypoxia Positive Regulation Of Cell Death Chromosome Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of MRNA 3'-end Processing Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Assembly Epithelium Development Response To Abiotic Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Cell Adhesion Tissue Development Biosynthetic Process Histone Modification Stem Cell Maintenance Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wnt Signaling Pathway Cell Development
Tagcloud ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey
Tagcloud (Difference) ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	adenomatous arhgap causative cntn6 cnv cnvs ctnnb1 etiologically filtered focad german germline hsph1 kiaa1797 kif26b mining mutyh ngs nonrecurrent polyposis predispose predisposition prioritized silico stringent truncating uncover unexplained ybey
Tagcloud (Intersection) ?