MCM3 and MCM4

Number of citations of the paper that reports this interaction (PMID 16902406)
42

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MCM3	MCM4
Gene Name		minichromosome maintenance complex component 3	minichromosome maintenance complex component 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Centrosome Membrane MCM Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Membrane MCM Complex
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 RPA2 STAT1 SUPT16H SYF2 YWHAQ	24 interactors: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 SSRP1 SUPT16H TLX2
Entrez ID		4172	4173
HPRD ID		04072	09094
Ensembl ID		ENSG00000112118	ENSG00000104738
Uniprot IDs		B4DUQ9 B4DWW4 P25205	B3KMX0 B4DLA6 P33991
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Cellular Response To Stress Chromosome Organization Cellular Metabolic Process DNA Repair Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition DNA Conformation Change DNA Damage Checkpoint Double-strand Break Repair Via Break-induced Replication Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process DNA Recombinase Assembly Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	DNA Replication G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Chromosome Organization Cellular Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition DNA Recombination DNA Conformation Change Regulation Of Cell Cycle Process Regulation Of DNA Replication DNA Recombinase Assembly Organelle Organization DNA Damage Checkpoint Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Cell Cycle Metabolic Process Response To Stress Positive Regulation Of DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle
Tagcloud ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Difference) ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Intersection) ?