MCM3 and RAD52

Number of citations of the paper that reports this interaction (PubMedID 15766559)
0

Data Source:
HPRD (in vitro, in vivo)

		MCM3	RAD52
Description		minichromosome maintenance complex component 3	RAD52 DNA repair protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Chromosome Nucleolus Cytoplasm Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
Drugs
Diseases
GWAS		Cryptococcosis in HIV infection ( 33269293)	Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		37 interacting genes: ATRIP CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 FILNC1 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		4172	5893
HPRD ID		04072	11855
Ensembl ID		ENSG00000112118	ENSG00000002016
Uniprot IDs		A0A0S2Z492 A0A0S2Z4T1 A0A499FHX9 B4DUQ9 J3KQ69 P25205	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Metabolic Process DNA Replication Nucleic Acid Metabolic Process DNA Replication Origin Binding Double-strand Break Repair Via Break-induced Replication Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response CMG Complex MCM Complex Regulation Of DNA Metabolic Process Regulation Of DNA Replication DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Macromolecule Metabolic Process Nucleus Double-strand Break Repair DNA Recombination Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Chromosome Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Single-stranded DNA Helicase Activity DNA Damage Checkpoint Signaling Origin Recognition Complex Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Signal Transduction In Response To DNA Damage DNA Helicase Activity Response To Stress Sister Chromatid Cohesion Prp19 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated DNA Replication ATP Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Helicase Activity Cyclin E1-CDK2 Complex	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress
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