MCM3 and RAD52

Number of citations of the paper that reports this interaction (PMID 15766559)
5

Data Source:
HPRD (in vitro, in vivo)

		MCM3	RAD52
Gene Name		minichromosome maintenance complex component 3	RAD52 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Centrosome Membrane MCM Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination
Pathways		Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA	Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Lung cancer ( 22899653)
Protein-Protein Interactions		31 interactors: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B RAD52 RPA2 STAT1 SUPT16H SYF2 YWHAQ	12 interactors: ABL1 ERCC2 ERCC3 ERCC4 MCM2 MCM3 RAD51 RPA1 RPA2 SUMO1 UBE2I WRN
Entrez ID		4172	5893
HPRD ID		04072	11855
Ensembl ID		ENSG00000112118	ENSG00000002016
Uniprot IDs		B4DUQ9 B4DWW4 P25205	F5GX32 P43351 Q3MI84 Q5DR82
PDB IDs			1H2I 1KN0
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Cellular Response To Stress Chromosome Organization Cellular Metabolic Process DNA Repair Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition DNA Conformation Change DNA Damage Checkpoint Double-strand Break Repair Via Break-induced Replication Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process DNA Recombinase Assembly Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle	DNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding DNA Geometric Change DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Organelle Organization Cellular Response To Stress Chromosome Organization Nucleotide-excision Repair DNA Strand Elongation Involved In DNA Replication DNA Recombinase Assembly DNA Strand Elongation DNA Conformation Change DNA Replication Nucleotide-excision Repair, DNA Incision DNA Catabolic Process Cell Cycle Process Double-strand Break Repair UV Protection Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Mitotic Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Response To UV Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Response To Radiation Aromatic Compound Catabolic Process Mismatch Repair Base-excision Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Catabolic Process DNA Unwinding Involved In DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis
Tagcloud ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Difference) ?		3k499a alanine archaeal atpases cerevisiae electrophoretic exception explanation hairpin hairpins helicase helicases inviability k499a mcm2 mcm7 mini probable ps1 reconstituted replicative saccharomyces sensor severely shaped subtly superfamily unwinding	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Intersection) ?