NPY and NPY2R

Number of citations of the paper that reports this interaction (PMID 7559383)
15

Data Source:
HPRD (in vivo)

		NPY	NPY2R
Gene Name		neuropeptide Y	neuropeptide Y receptor Y2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Golgi Apparatus	Plasma Membrane Integral Component Of Plasma Membrane Nonmotile Primary Cilium
	Molecular Function	G-protein Coupled Receptor Activity Receptor Binding Neuropeptide Hormone Activity Calcium Channel Regulator Activity Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding
	Biological Process	Calcium Ion Transport Movement Of Cell Or Subcellular Component G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Digestion Behavior Feeding Behavior Blood Circulation Regulation Of Blood Pressure Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Regulation Of Appetite Positive Regulation Of Appetite	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Locomotory Behavior Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Neurological System Process Positive Regulation Of Dopamine Secretion Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Secretion Negative Regulation Of Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Periodontitis ( 23459936)
Protein-Protein Interactions		15 interactors: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1	3 interactors: NPY PYY RGS12
Entrez ID		4852	4887
HPRD ID		01214	01216
Ensembl ID		ENSG00000122585	ENSG00000185149
Uniprot IDs		A4D158 P01303	P49146
PDB IDs		1QFA 1RON	2IK3
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Feeding Behavior Cell-cell Signaling Synaptic Transmission G-protein Coupled Receptor Signaling Pathway Behavior Digestion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Transport Negative Regulation Of Secretion Negative Regulation Of Feeding Behavior Outflow Tract Morphogenesis Peptide Hormone Secretion Peptide Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Hormone Secretion Regulation Of CAMP Biosynthetic Process Hormone Transport Cell Surface Receptor Signaling Pathway Peptide Transport Signal Transduction Regulation Of Secretion Regulation Of CAMP Metabolic Process Regulation Of Feeding Behavior Cellular Response To Stimulus Cardiac Left Ventricle Morphogenesis Response To Stimulus Membrane Depolarization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Response To Food Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Positive Regulation Of Circadian Rhythm Amide Transport Regulation Of Appetite Cell Communication Multicellular Organismal Reproductive Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organism Reproduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Chemical Homeostasis Negative Regulation Of Secretion By Cell Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Negative Regulation Of Insulin Secretion Regulation Of Cellular Localization	Regulation Of Appetite Neuropeptide Signaling Pathway Feeding Behavior Digestion Positive Regulation Of Appetite Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Behavior Regulation Of Response To Food Cell Proliferation Eating Behavior Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction
Tagcloud ?		anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular	adaptations anticonvulsive bdnf conducting decades differing ecs ect egr1 electroconvulsive fos inverse neuritin neuropeptides npy1r npy5r nrn points psd95 quantities seizures snap29 syn synapsin synaptotagmin syt transitory underline
Tagcloud (Difference) ?		anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular	adaptations anticonvulsive bdnf conducting decades differing ecs ect egr1 electroconvulsive fos inverse neuritin neuropeptides npy1r npy5r nrn points psd95 quantities seizures snap29 syn synapsin synaptotagmin syt transitory underline
Tagcloud (Intersection) ?