NPY and NPY4R

Number of citations of the paper that reports this interaction (PubMedID 7493937)
0

Data Source:
HPRD (in vitro)

		NPY	NPY4R
Description		neuropeptide Y	neuropeptide Y receptor Y4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding	Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis	Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Signaling
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Phentermine 2-aminoisobutyric acid L-tyrosinamide	Peptide YY (3-36) Obinepitide TM30339
Diseases
GWAS		Adiponectin levels ( 33562295) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Retinitis pigmentosa ( 33514863) Vitamin D levels ( 25208829)
Interacting Genes		16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2	3 interacting genes: NPY PPY PYY
Entrez ID		4852	5540
HPRD ID		01214	03476
Ensembl ID		ENSG00000122585	ENSG00000204174
Uniprot IDs		A4D158 P01303	P50391
PDB IDs		1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O	7X9C
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport	Neuropeptide Y Receptor Binding Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Hormone Activity Intestinal Epithelial Cell Differentiation G Protein-coupled Receptor Signaling Pathway Short-day Photoperiodism Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Extracellular Space Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Regulation Of Eating Behavior Monocyte Activation Extracellular Region Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Adult Feeding Behavior Epithelial Cell Differentiation Positive Regulation Of Feeding Behavior Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Positive Regulation Of Behavior Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Response To Nutrient Levels Terminal Bouton Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development Negative Regulation Of Blood Pressure Regulation Of Acute Inflammatory Response Regulation Of Synaptic Vesicle Exocytosis Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cytosolic Calcium Ion Concentration Response To Fungus Antibacterial Humoral Response Neuron Cellular Homeostasis
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