NPY and NPY5R

Number of citations: 0 (PubMedID 12007534)
Data Source: HPRD (in vivo)

		NPY	NPY5R
Name		neuropeptide Y	neuropeptide Y receptor Y5
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Neuron Projection Presynapse GABA-ergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Neuropeptide Binding
	Biological Process	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Negative Regulation Of Glutamate Secretion Signaling Negative Regulation Of Synaptic Transmission, GABAergic Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Generation Of Ovulation Cycle Rhythm Positive Regulation Of ERK1 And ERK2 Cascade Synaptic Signaling Via Neuropeptide
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Phentermine 2-aminoisobutyric acid L-tyrosinamide	Peptide YY (3-36)
GWAS		Adiponectin levels ( 33562295 ) Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Aggressive periodontitis (sex interaction) ( 25256105 ) Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Morning person ( 30696823 ) Periodontitis ( 23459936 ) Retinitis pigmentosa ( 33514863 ) Vitamin D levels ( 25208829 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2	4 interacting genes: NPY NUPR1 PYY RNF181
Entrez ID		4852	4889
HPRD ID		01214	03591
Ensembl ID		ENSG00000122585	ENSG00000164129
Uniprot IDs		A4D158 P01303	Q15761
PDB IDs		1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O	Not available
GO Terms Enriched among Interactors		Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport	Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Short-day Photoperiodism Hormone Activity Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Regulation Of Female Gonad Development Regulation Of Eating Behavior Monocyte Activation Negative Regulation Of Acute Inflammatory Response Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Adult Feeding Behavior Positive Regulation Of Feeding Behavior Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Autophagosome Assembly Fibroblast Apoptotic Process Regulation Of Type B Pancreatic Cell Proliferation Acetyltransferase Activator Activity Positive Regulation Of Cellular Respiration Epithelial Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Inflammatory Response Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Regulation Of Dopamine Metabolic Process Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Glycolytic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Oxidative Phosphorylation Neuronal Dense Core Vesicle Regulation Of Appetite Negative Regulation Of ATP Metabolic Process Photoperiodism Regulation Of Feeding Behavior Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Aerobic Respiration Positive Regulation Of Behavior