MC1R

Gene Name		melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organismal Development UV Protection Positive Regulation Of Protein Kinase A Signaling Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Basal cell carcinoma ( 21700618) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Melanoma ( 21983787 19578364) Non-melanoma skin cancer ( 23548203) Red vs non-red hair color ( 17952075) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518)
Protein-protein Interactions		3 interactors: ASIP MC4R POMC
Entrez ID		4157
HPRD ID		01118
Ensembl ID		ENSG00000258839
Uniprot IDs		Q01726 Q1JUL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Generation Of Precursor Metabolites And Energy Cellular Pigmentation Feeding Behavior Cell-cell Signaling Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Hormone Levels Regulation Of Corticosterone Secretion Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Regulation Of Feeding Behavior Behavior Positive Regulation Of Bone Resorption Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Positive Regulation Of Tissue Remodeling Genetic Imprinting Regulation Of Bone Resorption Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization Insulin Secretion Regulation Of Bone Remodeling G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Positive Regulation Of CAMP Biosynthetic Process Peptide Hormone Secretion Regulation Of Tissue Remodeling Peptide Secretion Positive Regulation Of CAMP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Signal Transduction Regulation Of CAMP Biosynthetic Process
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1