MC1R and ICAM1

Data Source: HiPPIP (Novel)

		MC1R	ICAM1
Name		melanocortin 1 receptor	intercellular adhesion molecule 1
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway UV Protection Regulation Of Gene Expression Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Feeding Behavior UV-damage Excision Repair Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Feeding Behavior	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Afamelanotide CZEN 002 Bremelanotide	Natalizumab Hyaluronic acid Nafamostat
Diseases		None	Allograft rejection
GWAS		Basal cell carcinoma ( 27539887 21700618 31174203 ) Black vs. non-black hair color ( 26184321 ) Black vs. red hair color ( 18483556 ) Blond vs. brown hair color ( 17952075 ) Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Brown vs. black hair color ( 30531825 ) Brown vs. non-brown hair color ( 26184321 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous melanoma or hair colour ( 32341527 ) Cutaneous squamous cell carcinoma ( 27424798 ) Facial pigmentation ( 25705849 ) Facial pigmentation measurement (polar light) ( 32835660 ) Facial pigmentation measurement (UV light) ( 32835660 ) Freckles ( 17952075 ) Freckling ( 20585627 ) Hair color ( 20585627 29662168 23548203 ) Hair morphology traits ( 30166351 ) Hemoglobin levels ( 32327693 ) Keratinocyte cancer (MTAG) ( 31174203 ) Light vs. dark hair color ( 26184321 ) Low tan response ( 29739929 ) Melanoma ( 19578364 21983787 28212542 24980573 ) Metabolite levels ( 23823483 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Non-melanoma skin cancer ( 29739929 23548203 ) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744 ) Perceived skin darkness ( 25963972 ) Red vs non-red hair color ( 26184321 17952075 ) Red vs. brown/black hair color ( 30531825 ) Skin aging (microtopography measurement) ( 28502801 ) Skin colour saturation ( 25963972 ) Skin pigmentation ( 30664655 ) Skin pigmentation traits ( 30166351 ) Skin sensitivity to sun ( 25963972 17952075 ) Squamous cell carcinoma ( 26829030 ) Sunburns ( 23548203 ) Tanning ( 23548203 19340012 ) Vitiligo ( 22561518 27723757 ) Youthful appearance (self-reported) ( 32339537 )	Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 ) Height ( 31562340 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low white blood cell count (conditioned on rs2814778) ( 29596498 ) Lymphocyte count ( 27863252 32888494 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Soluble ICAM-1 ( 18604267 21533024 31217265 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: ICAM1	12 novel interactors: BCL7B BRAF CALR FANCF HDAC1 KIF1A MAP2K7 MC1R MTPN MYO1F SLCO2B1 TBL3
Interacting Genes		3 interacting genes: ASIP MC4R POMC	16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2
Entrez ID		4157	3383
HPRD ID		01118	00996
Ensembl ID		ENSG00000258839	ENSG00000090339
Uniprot IDs		Q01726 Q1JUL4	A0A384MEK5 P05362
PDB IDs		7F4D 7F4F 7F4H 7F4I	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
GO Terms Enriched among Interactors		Response To Melanocyte-stimulating Hormone Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Pigmentation Feeding Behavior Melanocortin Receptor Binding Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Oxytocin Production Positive Regulation Of Neutrophil Mediated Killing Of Fungus Carbohydrate Homeostasis T Cell Antigen Processing And Presentation Glucose Homeostasis Melanocyte-stimulating Hormone Receptor Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Membrane To Membrane Docking T Cell Extravasation Melanocortin Receptor Activity Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Receptor-mediated Virion Attachment To Host Cell T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Response To Peptide Hormone Regulation Of Eating Behavior Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Adult Feeding Behavior Extracellular Space Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Signaling Receptor Binding Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Adhesion Of Symbiont To Host Positive Regulation Of Bone Resorption Positive Regulation Of Cellular Extravasation Cellular Extravasation Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Regulation Of Hormone Levels Regulation Of Appetite Pigment Granule Localization Neuropeptide Binding	Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion