MC1R and POMC

Number of citations of the paper that reports this interaction (PMID 9058374)
19

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MC1R	POMC
Gene Name		melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	proopiomelanocortin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organismal Development UV Protection Positive Regulation Of Protein Kinase A Signaling Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Feeding Behavior	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Peptide Hormone Processing Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins G alpha (s) signalling events Glucocorticoid biosynthesis Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Peptide hormone metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Peptide ligand-binding receptors Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Peptide hormone biosynthesis G alpha (i) signalling events Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Opioid Signalling Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) GPCR ligand binding Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) GPCR downstream signaling Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) G-protein activation Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Basal cell carcinoma ( 21700618) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Melanoma ( 21983787 19578364) Non-melanoma skin cancer ( 23548203) Red vs non-red hair color ( 17952075) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518)	Body mass index ( 23669352 20935630) Height ( 23563607 18391951) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		3 interactors: ASIP MC4R POMC	12 interactors: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRD1 PAM VTN
Entrez ID		4157	5443
HPRD ID		01118	01462
Ensembl ID		ENSG00000258839	ENSG00000115138
Uniprot IDs		Q01726 Q1JUL4	P01189 Q6FHC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Generation Of Precursor Metabolites And Energy Cellular Pigmentation Feeding Behavior Cell-cell Signaling Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Hormone Levels Regulation Of Corticosterone Secretion Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Regulation Of Feeding Behavior Behavior Positive Regulation Of Bone Resorption Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Positive Regulation Of Tissue Remodeling Genetic Imprinting Regulation Of Bone Resorption Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization Insulin Secretion Regulation Of Bone Remodeling G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Positive Regulation Of CAMP Biosynthetic Process Peptide Hormone Secretion Regulation Of Tissue Remodeling Peptide Secretion Positive Regulation Of CAMP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Signal Transduction Regulation Of CAMP Biosynthetic Process	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Behavior Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Neuromuscular Junction Development Innate Immune Response Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Positive Regulation Of White Fat Cell Proliferation Semicircular Canal Fusion Bronchiole Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Lung Development Response To Stimulus Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of White Fat Cell Proliferation Synaptic Growth At Neuromuscular Junction Tear Secretion Semicircular Canal Formation Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Peptide Amidation Homoiothermy Feeding Behavior Signal Transduction Positive Regulation Of Fat Cell Proliferation Bronchiole Development Submandibular Salivary Gland Formation Female Genitalia Morphogenesis Collateral Sprouting In Absence Of Injury
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary releasing steroid superfamily transformants transiently
Tagcloud (Intersection) ?		proopiomelanocortin