MC1R and ASIP

Number of citations of the paper that reports this interaction (PMID 9058374)
19

Data Source:
HPRD (in vivo)

		MC1R	ASIP
Gene Name		melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	agouti signaling protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding	Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organismal Development UV Protection Positive Regulation Of Protein Kinase A Signaling Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Feeding Behavior	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Genetic Imprinting
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Basal cell carcinoma ( 21700618) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Melanoma ( 21983787 19578364) Non-melanoma skin cancer ( 23548203) Red vs non-red hair color ( 17952075) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518)	Breast cancer ( 22976474) Burning and freckling ( 18488028) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Melanoma ( 21983787) Red vs. non-red hair color ( 18488028) Skin sensitivity to sun ( 18488028) Tanning ( 23548203)
Protein-Protein Interactions		3 interactors: ASIP MC4R POMC	6 interactors: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4157	434
HPRD ID		01118	02562
Ensembl ID		ENSG00000258839	ENSG00000101440
Uniprot IDs		Q01726 Q1JUL4	P42127
PDB IDs			1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Generation Of Precursor Metabolites And Energy Cellular Pigmentation Feeding Behavior Cell-cell Signaling Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Hormone Levels Regulation Of Corticosterone Secretion Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior Response To Nutrient Levels Response To Extracellular Stimulus Adult Feeding Behavior Regulation Of Feeding Behavior Behavior Positive Regulation Of Bone Resorption Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Pigment Granule Organization Secondary Metabolite Biosynthetic Process Positive Regulation Of Tissue Remodeling Genetic Imprinting Regulation Of Bone Resorption Peptide Hormone Processing Melanosome Transport Pigment Granule Transport Response To Hormone Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Melanosome Localization Insulin Secretion Regulation Of Bone Remodeling G-protein Coupled Receptor Signaling Pathway Pigment Biosynthetic Process Positive Regulation Of CAMP Biosynthetic Process Peptide Hormone Secretion Regulation Of Tissue Remodeling Peptide Secretion Positive Regulation Of CAMP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Signal Transduction Regulation Of CAMP Biosynthetic Process	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Feeding Behavior Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Homoiothermy Regulation Of Blood Pressure Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Protein Kinase A Signaling UV-damage Excision Repair Establishment Of Endothelial Intestinal Barrier Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Response To Stimulus Regulation Of Grooming Behavior Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Rho GTPase Activity UV Protection Positive Regulation Of Bone Resorption Regulation Of Protein Kinase A Signaling Positive Regulation Of Rap GTPase Activity Regulation Of Protein Kinase C Signaling Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Negative Regulation Of Ras GTPase Activity Response To Radiation Regulation Of Rap GTPase Activity Secondary Metabolite Biosynthetic Process Intestinal Absorption Sodium Ion Homeostasis Temperature Homeostasis Regulation Of Rap Protein Signal Transduction
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1