NELL2 and PRKAR1A

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		NELL2	PRKAR1A
Name		neural EGFL like 2	protein kinase cAMP-dependent type I regulatory subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Nervous System Development Fertilization Neuron Cellular Homeostasis Commissural Neuron Axon Guidance	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Regulation of commissural axon pathfinding by SLIT and ROBO	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		None	(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		None	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Inflammatory bowel disease ( 27569725 ) Waist circumference ( 28552196 )	Body size at age 10 ( 32376654 ) Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 31152163 ) Intake of total sugars ( 31005972 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		1 novel interactors: BRD4	None recorded
Interacting Genes		9 interacting genes: ARX ATN1 ATXN7 CACNA1A DYRK1A GFI1B HOXA1 MBD1 PRKAR1A	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		4753	5573
HPRD ID		11891	01786
Ensembl ID		ENSG00000184613	ENSG00000108946
Uniprot IDs		B7Z625 Q99435	B2R5T5 P10644
PDB IDs		6POG	5KJX 5KJY 5KJZ
GO Terms Enriched among Interactors		Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Regulation Of Metabolic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Histone H4K8ac Reader Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Metabolic Process Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Or Depolymerization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Globus Pallidus Development Negative Regulation Of Metabolic Process P-TEFb Complex Binding Histone H4 Reader Activity Lipid Digestion Cerebral Cortex Tangential Migration Negative Regulation Of Heterochromatin Formation	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding