NELL2 and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		NELL2	ATXN7
Gene Name		NEL-like 2 (chicken)	ataxin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Calcium Ion Binding Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Neuron Cellular Homeostasis	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATN1 ATXN7 CACNA1A GFI1B PRKAR1A	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		4753	6314
HPRD ID		11891	06365
Ensembl ID		ENSG00000184613	ENSG00000163635
Uniprot IDs		B7Z625 Q99435	O15265 Q9UPD8
PDB IDs			2KKR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cerebellar Molecular Layer Development Energy Reserve Metabolic Process Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Insulin Secretion Gamma-aminobutyric Acid Secretion Regulation Of Peptide Hormone Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Regulation Of Hormone Secretion Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of CAMP-dependent Protein Kinase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Biosynthetic Process Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Pons Development Maintenance Of Cell Polarity Negative Regulation Of Phosphorylation Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Protein Secretion Toxin Metabolic Process Generation Of Precursor Metabolites And Energy Activation Of Protein Kinase A Activity Cerebellar Purkinje Cell Differentiation Negative Regulation Of Meiotic Nuclear Division Regulation Of Metabolic Process Cerebellar Purkinje Cell Layer Morphogenesis Cardiac Muscle Cell Proliferation Growth Histone Deubiquitination System Development Reflex Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Meiotic Cell Cycle Regulation Of Transcription, DNA-templated Behavioral Response To Pain Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K4 Methylation Neuromuscular Synaptic Transmission Regulation Of RNA Metabolic Process Regulation Of Hormone Biosynthetic Process	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?		antiapoptotic apoptotic caspases chaperones chop cleaved context continuous cos7 cytoprotective decreasing ebp endoplasmic environments er homeostasis homologous inducer intra pro protection reticulum stress stresses thapsigargin triggers u0126 unfolded xl	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?		antiapoptotic apoptotic caspases chaperones chop cleaved context continuous cos7 cytoprotective decreasing ebp endoplasmic environments er homeostasis homologous inducer intra pro protection reticulum stress stresses thapsigargin triggers u0126 unfolded xl	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?