MATN1 and COL2A1

Number of citations of the paper that reports this interaction (PubMedID 10196235)
0

Data Source:
HPRD (in vivo)

		MATN1	COL2A1
Description		matrilin 1	collagen type II alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Matrilin Complex	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Basement Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Morphogenesis Extracellular Matrix Organization Regulation Of Bone Mineralization Protein-containing Complex Assembly	Skeletal System Development Cartilage Condensation Ossification Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Collagen Fibril Organization Notochord Development Limb Morphogenesis Inner Ear Morphogenesis Animal Organ Development Skeletal System Morphogenesis System Development Inner Ear Development Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum
Diseases			Osteoarthritis with mild chondrodysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS		Broad depression or schizophrenia ( 30626913) Low high density lipoprotein cholesterol levels ( 26879886) Monocyte count ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 30285260) Serum alkaline phosphatase levels ( 33339817)	Lymphocyte count ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		5 interacting genes: COL2A1 ITGA1 MATN2 MATN3 MATN4	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		4146	1280
HPRD ID		00276	00361
Ensembl ID		ENSG00000162510	ENSG00000139219
Uniprot IDs		P21941	P02458
PDB IDs			1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6HG7 6NIX 7NZE
Enriched GO Terms of Interacting Partners?		Matrilin Complex Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Extracellular Matrix Structural Constituent Basement Membrane Cartilage Development Integrin Alpha1-beta1 Complex Dendrite Regeneration Calcium Ion Binding Collagen Type II Trimer Lactose Synthase Activity Collagen Type XI Trimer Skeletal System Development Anterior Head Development Collagen Binding Involved In Cell-matrix Adhesion N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity MHC Class II Protein Binding Phosphatase Activator Activity Galactosyltransferase Activity Otic Vesicle Development Extracellular Region Fibrillar Collagen Trimer Limb Bud Formation Notochord Development Platelet-derived Growth Factor Binding Cerebellar Purkinje Cell Layer Development Embryonic Skeletal Joint Morphogenesis Endoplasmic Reticulum Lumen Proteoglycan Binding Basal Part Of Cell Cellular Extravasation Cartilage Condensation Cartilage Development Involved In Endochondral Bone Morphogenesis	Extracellular Matrix Extracellular Region Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Animal Organ Development Cartilage Development Extracellular Matrix Binding Platelet Alpha Granule Lumen Developmental Process Cell Surface Extracellular Matrix Organization Extracellular Structure Organization Animal Organ Morphogenesis Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Response To Wounding Anatomical Structure Morphogenesis Bone Development Heparin Binding Positive Regulation Of Cell Migration Positive Regulation Of Glial Cell Differentiation Basement Membrane Positive Regulation Of Cell Motility Platelet-derived Growth Factor Binding Golgi Lumen Tube Morphogenesis Positive Regulation Of Locomotion Angiogenesis Regulation Of Cell Adhesion Extracellular Exosome Proteoglycan Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Bone Mineralization Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Chondrocyte Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Gliogenesis Positive Regulation Of Phosphorylation Collagen Metabolic Process Regulation Of Extracellular Matrix Organization Regulation Of Glial Cell Differentiation Connective Tissue Development
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