MATN1 and MATN3

Number of citations of the paper that reports this interaction (PubMedID 11896063)
0

Data Source:
HPRD (in vitro)

		MATN1	MATN3
Description		matrilin 1	matrilin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Matrilin Complex	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Matrilin Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Morphogenesis Extracellular Matrix Organization Regulation Of Bone Mineralization Protein-containing Complex Assembly	Skeletal System Development Extracellular Matrix Organization Cartilage Development
Pathways		ECM proteoglycans	ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			SEMD, Matrilin type; Spondyloepimetaphyseal dysplasia Multiple epiphyseal dysplasia (MED)
GWAS		Broad depression or schizophrenia ( 30626913) Low high density lipoprotein cholesterol levels ( 26879886) Monocyte count ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 28991256 30285260) Serum alkaline phosphatase levels ( 33339817)	Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		5 interacting genes: COL2A1 ITGA1 MATN2 MATN3 MATN4	6 interacting genes: INCA1 KRTAP10-8 MATN1 MATN4 NOTCH2NLA TCF4
Entrez ID		4146	4148
HPRD ID		00276	03661
Ensembl ID		ENSG00000162510	ENSG00000132031
Uniprot IDs		P21941	O15232
PDB IDs
Enriched GO Terms of Interacting Partners?		Matrilin Complex Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Extracellular Matrix Structural Constituent Basement Membrane Cartilage Development Integrin Alpha1-beta1 Complex Dendrite Regeneration Calcium Ion Binding Collagen Type II Trimer Lactose Synthase Activity Collagen Type XI Trimer Skeletal System Development Anterior Head Development Collagen Binding Involved In Cell-matrix Adhesion N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity MHC Class II Protein Binding Phosphatase Activator Activity Galactosyltransferase Activity Otic Vesicle Development Extracellular Region Fibrillar Collagen Trimer Limb Bud Formation Notochord Development Platelet-derived Growth Factor Binding Cerebellar Purkinje Cell Layer Development Embryonic Skeletal Joint Morphogenesis Endoplasmic Reticulum Lumen Proteoglycan Binding Basal Part Of Cell Cellular Extravasation Cartilage Condensation Cartilage Development Involved In Endochondral Bone Morphogenesis	Matrilin Complex Growth Plate Cartilage Chondrocyte Morphogenesis Calcium Ion Binding Beta-catenin-TCF7L2 Complex TFIIB-class Transcription Factor Binding Extracellular Structure Organization Extracellular Matrix Organization Cartilage Morphogenesis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Beta-catenin-TCF Complex Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
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