MATN1 and ITGA1

Number of citations of the paper that reports this interaction (PMID 10196235)
11

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		MATN1	ITGA1
Gene Name		matrilin 1, cartilage matrix protein	integrin, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding	Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Growth Plate Cartilage Chondrocyte Morphogenesis Protein Complex Assembly Extracellular Matrix Organization Regulation Of Bone Mineralization	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation
Pathways		ECM proteoglycans	Platelet Adhesion to exposed collagen CHL1 interactions Axon guidance Laminin interactions Semaphorin interactions Other semaphorin interactions Smooth Muscle Contraction L1CAM interactions Integrin cell surface interactions
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		5 interactors: COL2A1 ITGA1 MATN2 MATN3 MATN4	10 interactors: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		4146	3672
HPRD ID		00276	01892
Ensembl ID		ENSG00000162510
Uniprot IDs		P21941	P56199
PDB IDs			1PT6 1QC5 1QCY 2L8S 4A0Q
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To Axon Injury Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Dendrite Regeneration Response To Wounding Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Limb Bud Formation Movement Of Cell Or Subcellular Component Generation Of Neurons Positive Regulation Of Phosphoprotein Phosphatase Activity Neurogenesis Otic Vesicle Development Cell Development Response To External Stimulus System Development Embryonic Skeletal Joint Morphogenesis Embryonic Skeletal Joint Development Notochord Development Cartilage Condensation Skeletal System Development Cellular Response To BMP Stimulus Cellular Extravasation Positive Regulation Of Phosphatase Activity Multicellular Organismal Development Vasodilation Regulation Of Phosphoprotein Phosphatase Activity Anatomical Structure Development Nervous System Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Anatomical Structure Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Dephosphorylation Negative Regulation Of ERBB Signaling Pathway Neuron Projection Regeneration Neutrophil Chemotaxis	Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization System Development Multicellular Organismal Development Anatomical Structure Development Cell Adhesion Developmental Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Organ Development Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Tissue Development Collagen Catabolic Process Cellular Component Assembly Organ Morphogenesis Axon Guidance Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-2-mediated Signaling Pathway Collagen Metabolic Process Cell Morphogenesis Blood Vessel Morphogenesis Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Endocytosis B Cell Differentiation Negative Regulation Of Inflammatory Response Blood Vessel Development Nervous System Development Lipid Tube Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Cell-cell Junction Assembly Axonogenesis Vasculature Development Bone Morphogenesis Axon Development Formation Of Primary Germ Layer
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