MAGEA6 and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA6	PCBD2
Description		MAGE family member A6	pterin-4 alpha-carbinolamine dehydratase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Mitochondrion
	Molecular Function	Protein Binding Histone Deacetylase Binding	Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951 28552196) Type 2 diabetes ( 24509480)
Interacting Genes		75 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76	41 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY USP2-AS1 XBP1 ZZZ3
Entrez ID		4105	84105
HPRD ID		02168	17824
Ensembl ID		ENSG00000197172	ENSG00000132570
Uniprot IDs		P43360	Q9H0N5
PDB IDs			4C45
Enriched GO Terms of Interacting Partners?		Protein Binding SNARE Complex Suppression Of Viral Release By Host	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Core Mediator Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Mediator Complex Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II Preinitiation Complex Assembly Nuclear Vitamin D Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Coregulator Activity Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-1 Beta Production Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Metabolic Process Transcription Corepressor Activity Ubiquitin Ligase Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Interleukin-1 Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Stem Cell Population Maintenance
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