MAGEA6 and APOA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEA6	APOA4
Description		MAGE family member A6	apolipoprotein A4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Protein Binding Histone Deacetylase Binding	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy	Innate Immune Response In Mucosa Lipid Transport Response To Stress Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Peripheral Nervous System Axon Regeneration Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Triglyceride Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Lipid Homeostasis Acylglycerol Homeostasis Protein-lipid Complex Assembly
Pathways			Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817)	Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 26582766 20864672 20686565 19060906) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20686565 20864672 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 29615537 28334899 29403010) Triglyceride levels ( 26763881 32335043 32203549 29615537 28371326 28334899) Triglycerides ( 20139978 20686565 20864672 19074352 19060911 19060906 21909109 26582766 18193044 18193043)
Interacting Genes		75 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76	6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6
Entrez ID		4105	337
HPRD ID		02168	00130
Ensembl ID		ENSG00000197172	ENSG00000110244
Uniprot IDs		P43360	P06727
PDB IDs			3S84
Enriched GO Terms of Interacting Partners?		Protein Binding SNARE Complex Suppression Of Viral Release By Host	Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity CTP Binding DATP Binding Cellular Response To Triglyceride Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Histone Deacetylase Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Rho GDP-dissociation Inhibitor Binding Positive Regulation Of Phosphatase Activity Negative Regulation Of Triglyceride Catabolic Process Response To Triglyceride Phospholipase D Activity Positive Regulation Of Dephosphorylation Hematopoietic Stem Cell Migration To Bone Marrow Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Angiotensin Type II Receptor Activity Positive Regulation Of Protein Catabolic Process Hematopoietic Stem Cell Migration Regulation Of Phosphatase Activity Positive Regulation Of Protein Transport Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding
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