MAGEA6 and HLA-DRB4

Number of citations of the paper that reports this interaction (PMID 12631591)
12

Data Source:
BioGRID (unspecified method)

		MAGEA6	HLA-DRB4
Gene Name		melanoma antigen family A, 6	major histocompatibility complex, class II, DR beta 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Biological_process	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Peptide Antigen Assembly With MHC Class II Protein Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response Signal Transduction Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ACOT7 AKAP9 ANKRD26P1 ATP6V1G1 ATPAF2 BCL7B BET1 CCDC146 CTF1 ELMOD3 EXOC5 FAM214A FRMPD1 GFOD1 HAUS1 HLA-DRB4 IQUB KLHL38 LCORL LIN37 LSM2 MIPOL1 MORN3 NCK2 PDE4D RASSF4 RCOR3 RPL37A S100A14 SH2D4A SNAP47 SNX4 STAMBPL1 STX5 TRIM28 TULP3 TXNDC9	3 interactors: ASMTL CTAG1B MAGEA6
Entrez ID		4105	3126
HPRD ID		02168	09986
Ensembl ID		ENSG00000197172
Uniprot IDs		P43357 P43360	P13762
PDB IDs		1QEW
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Vesicle Fusion With Golgi Apparatus Organelle Fusion Vesicle Organization Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Membrane Fusion Cellular Protein Complex Assembly Protein Complex Assembly Palmitic Acid Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate
Tagcloud ?		aberrations accrued arid1a arid2 axon beauty cdkn2a epc1 exome guidance informative integrative map2k4 mll3 nalcn reaffirming recapitulated recurrently robo sf3b1 slc16a4 sleeping slit smad4 supportive tgfbr2 transposon uncover zim2
Tagcloud (Difference) ?		aberrations accrued arid1a arid2 axon beauty cdkn2a epc1 exome guidance informative integrative map2k4 mll3 nalcn reaffirming recapitulated recurrently robo sf3b1 slc16a4 sleeping slit smad4 supportive tgfbr2 transposon uncover zim2
Tagcloud (Intersection) ?