MAGEA6 and MED21

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		MAGEA6	MED21
Description		MAGE family member A6	mediator complex subunit 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Histone Deacetylase Binding	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy	Blastocyst Development Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		75 interacting genes: ACOT7 ACTN3 AKAP9 ANKRD26P1 APOA4 ARFIP1 ATOSA ATP6V1G1 ATPAF2 BCL7B BET1 BFSP2 BOLA3 C1orf216 CAMTA2 CBFA2T2 CCDC146 CCDC185 CCDC187 CCDC24 COL4A6 CTF1 DLGAP3 DLGAP4 DNTTIP1 ELMOD3 EXOC5 FRMPD1 GADD45GIP1 GCSH GFOD1 HAUS1 HLA-DRB4 HNRNPM IQUB KIF27 KLHL38 LCORL LIN37 LIN52 LSM2 MCM7 MCRS1 MED21 MID2 MIPOL1 MORN3 MSGN1 NCK2 NOSTRIN PCBD2 PDE4D PRKAA1 RASSF10 RASSF4 RCOR3 REX1BD RPL37A RUSC1 S100A14 S100A9 SH2D4A SMARCD1 SNAP47 SNX4 SON STAMBPL1 STX5 TRIM26 TRIM28 TSPYL6 TULP3 TXNDC9 XRCC4 ZNF76	30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 CEBPA ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1
Entrez ID		4105	9412
HPRD ID		02168	09156
Ensembl ID		ENSG00000197172	ENSG00000152944
Uniprot IDs		P43360	A0A024RAW0 Q13503
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Protein Binding SNARE Complex Suppression Of Viral Release By Host	DNA-templated Transcription Nuclear Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Transcription Coactivator Binding Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Female Courtship Behavior RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding MRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Nuclear Estrogen Receptor Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Thyroid Hormone Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process
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