RASD2 and GNB2

Number of citations of the paper that reports this interaction (PubMedID 19255495)
0

Data Source:
BioGRID (two hybrid)

		RASD2	GNB2
Description		RASD family member 2	G protein subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Extracellular Space Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Vesicle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding G-protein Beta-subunit Binding	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding
	Biological Process	Synaptic Transmission, Dopaminergic Signal Transduction Locomotory Behavior Positive Regulation Of Protein Sumoylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport
Pathways			Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Chronotype ( 30696823) Hippocampal volume in mild cognitive impairment ( 29274321) Intelligence (MTAG) ( 29326435) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693)
Interacting Genes		16 interacting genes: ACVR1 BMPR1B GNB1 GNB2 GNB3 PIK3CA PIK3R1 RABAC1 RAF1 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SMURF2 TGFBR1	32 interacting genes: ANXA7 ATXN10 CAPNS1 CDKN1A CFTR CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 ID3 MTNR1B NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		23551	2783
HPRD ID		15210	11820
Ensembl ID		ENSG00000100302	ENSG00000172354
Uniprot IDs		Q96D21	P62879 Q6FHM2
PDB IDs			9AVL
Enriched GO Terms of Interacting Partners?		I-SMAD Binding SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Heteromeric SMAD Protein Complex Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I SMAD Protein Signal Transduction Response To Growth Factor Regulation Of Developmental Process R-SMAD Binding BMP Signaling Pathway Intracellular Glucose Homeostasis Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Trophoblast Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway GTPase Binding Pattern Specification Process Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Extracellular Matrix Assembly Gastrulation Osteoblast Differentiation Ameboidal-type Cell Migration Tissue Development Regionalization Transmembrane Receptor Protein Serine/threonine Kinase Activity Co-SMAD Binding Cellular Response To Growth Factor Stimulus Primary MiRNA Processing Embryonic Pattern Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Signal Transduction Regulation Of SMAD Protein Signal Transduction Intracellular Signaling Cassette Response To Transforming Growth Factor Beta Cell Fate Commitment Positive Regulation Of Cell Differentiation Regulation Of Cartilage Development Positive Regulation Of Multicellular Organismal Process Homomeric SMAD Protein Complex Glucose Homeostasis	Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction Plasma Membrane Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Cell Division Membrane Response To Alcohol Negative Regulation Of Adenylate Cyclase Activity Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Synapse Ciliary Basal Body Wound Healing Cellular Response To Forskolin G Protein-coupled Receptor Binding Midbody Response To Forskolin Positive Regulation Of Programmed Cell Death PDZ Domain Binding Response To Wounding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Ketone Hematopoietic Or Lymphoid Organ Development Regulation Of Apoptotic Process Regulation Of Steroid Metabolic Process
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