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RPS27A and TGFBR1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
RPS27A
TGFBR1
Description
ribosomal protein S27a
transforming growth factor beta receptor 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Ribosome
Plasma Membrane
Endosome Membrane
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Endocytic Vesicle Membrane
Vesicle
Small-subunit Processome
Synapse
Extracellular Exosome
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Endosome
Plasma Membrane
Bicellular Tight Junction
Cilium
Cell Surface
Membrane
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Anchoring Junction
Serine/threonine Protein Kinase Complex
Molecular Function
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Zinc Ion Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Growth Factor Binding
Ubiquitin Protein Ligase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
I-SMAD Binding
Biological Process
Cytoplasmic Translation
Translation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Ribosomal Small Subunit Biogenesis
Skeletal System Development
Angiogenesis
In Utero Embryonic Development
Kidney Development
Blastocyst Development
Epithelial To Mesenchymal Transition
Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Proepicardium Development
Regulation Of DNA-templated Transcription
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Male Gonad Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Peptidyl-serine Phosphorylation
Cell Differentiation
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Regulation Of Protein Ubiquitination
Negative Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Intracellular Signal Transduction
Myofibroblast Differentiation
Wound Healing
Endothelial Cell Activation
Extracellular Structure Organization
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Endothelial Cell Migration
Positive Regulation Of DNA-templated Transcription
Filopodium Assembly
Thymus Development
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Mesenchymal Cell Differentiation
Artery Morphogenesis
Cell Motility
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Parathyroid Gland Development
Roof Of Mouth Development
Pharyngeal System Development
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Epithelial To Mesenchymal Transition
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Trophoblast Cell Migration
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Alcohol
Vascular Endothelial Cell Proliferation
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Positive Regulation Of Vasculature Development
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Tight Junction Disassembly
Epicardium Morphogenesis
Regulation Of Multicellular Organismal Development
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
VLDLR internalisation and degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Interferon alpha/beta signaling
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Signaling by CSF1 (M-CSF) in myeloid cells
Maturation of protein E
SARS-CoV-1 activates/modulates innate immune responses
Maturation of protein E
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Regulation of BACH1 activity
Signaling by ALK fusions and activated point mutants
SARS-CoV-1 modulates host translation machinery
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SARS-CoV-2 modulates host translation machinery
KEAP1-NFE2L2 pathway
Regulation of NF-kappa B signaling
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Amyloid fiber formation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
Regulation of pyruvate metabolism
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PD-L1(CD274) glycosylation and translocation to plasma membrane
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Ub-specific processing proteases
TGFBR3 regulates TGF-beta signaling
Drugs
4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
Naphthyridine Inhibitor
3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
23455636
)
Asthma (
31959851
32296059
34103634
)
Callous-unemotional behaviour (
23874384
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Dental caries (
23064961
)
Epithelial ovarian cancer (
25134534
)
Fractures (paediatric) (
32742401
)
Gestational age at birth (maternal effect) (
28877031
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
41 interacting genes:
ACVR1
APP
BACH1
BMPR1B
CALCOCO2
CDC6
CDK11B
DAZAP2
DESI1
DNAJB2
EPN2
EPN3
FAM168A
FOXP1
FSHR
GGA1
GGA3
KANSL3
LITAF
MAST2
MTURN
PAXIP1
PLEKHB2
PLSCR4
POLH
PTEN
RABGEF1
RAD23A
RBPMS
RNF11
RNF26
SMAD1
SMAD2
SMAD4
SMURF1
SMURF2
TGFBR1
TRAF6
UBQLN1
WBP2
ZNF512B
164 interacting genes:
ACVR1
ACVRL1
AMHR2
ANAPC5
AP2B1
ARHGAP15
ARHGAP31
ARHGEF6
ARL4D
ARL8B
ASH2L
AURKB
BAMBI
BMPR1B
BMPR2
BTBD2
CAV1
CD44
CDC20
CDC42EP4
CDK14
CDK17
CDK4
CDK6
CDKL1
CHN1
CHN2
CHUK
CLU
CSNK1A1
CSNK2A2
CTNNB1
CUL5
DAB2
DAPK2
DCAF12
DCAF6
DUSP13B
EIF2AK4
ENC1
ENG
FANCL
FBXL12
FBXO34
FKBP1A
FKBP1B
FNTA
GNA13
GNB2
GNB3
IKBKB
ITK
KATNB1
KCNK18
KLHL1
KLHL35
LIMS1
LITATS1
MAP3K20
MAP3K7
MYO3A
MYOC
MYT1L
NAT8
NEK6
NEK8
NKIRAS1
NRP1
NUAK2
NUP37
OSR1
OTUB1
OXSR1
PAK1
PARD6A
PIK3R1
PIK3R2
PLEK
PLEKHB1
PLEKHJ1
PLK4
PML
POMK
PPP2R2A
PPP3CC
PPP6C
PREB
PREX2
PRPF4
RAB13
RAB25
RAB33B
RAB34
RAB38
RAB3B
RAB6B
RAN
RAP2A
RASD2
RASL12
RGS19
RHEBL1
RHOA
RHOD
RHOG
RHOH
RHOJ
RHPN2
RNF130
RNF146
RNF5
RPAP3
RPS27A
RRH
RTKN
SAMD8
SAT2
SKAP2
SKI
SKIC8
SMAD1
SMAD2
SMAD3
SMAD4
SMAD6
SMAD7
SMURF2
SNTG1
SNX6
SOCS6
SQSTM1
STK35
STRAP
STUB1
STX8
STYXL1
TGFB1
TGFB2
TGFB3
TGFBR2
TGFBRAP1
TNNT1
TRAF6
TRAP1
TSC22D1
TSSK1B
TSSK4
TTC1
TTC27
TTPAL
UBA52
UBB
UBD
UBE2E3
UBE2Z
UBXN1
USP14
USP2
USP45
VEPH1
WDR13
WDR33
XIAP
ZFYVE9
Entrez ID
6233
7046
HPRD ID
01878
01822
Ensembl ID
ENSG00000143947
ENSG00000106799
Uniprot IDs
B2RDW1
P62979
B4DXN7
B4DY26
F8W0K6
P36897
Q5T7S2
PDB IDs
2KHW
2KOX
2KTF
2KWU
2KWV
2L0F
2L0T
2XK5
3AXC
3I3T
3K9P
3N30
3N32
3NHE
3NOB
3NS8
3PHD
3PHW
3TBL
3VDZ
4R62
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5T2C
5WVO
5YDK
6DC6
6FEC
6G18
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6J99
6KFP
6KG6
6KIU
6KIV
6KIW
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6SQO
6SQR
6SQS
6XA1
6Y0G
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7BWD
7F0N
7JQB
7JQC
7K5I
7MQ9
7MQA
7OOJ
7QP6
7QP7
7R4X
7TQL
7WTT
7WTU
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNY
8G5Y
8G60
8G61
8G6J
8GLP
8HTC
8HTF
8IFD
8IFE
8IVB
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8X7I
8X7J
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
9IJU
9IML
9IPU
1B6C
1IAS
1PY5
1RW8
1VJY
2L5S
2PJY
2WOT
2WOU
2X7O
3FAA
3GXL
3HMM
3KCF
3KFD
3TZM
4X0M
4X2F
4X2G
4X2J
4X2K
4X2N
5E8S
5E8T
5E8U
5E8W
5E8X
5E8Z
5E90
5FRI
5QIK
5QIL
5QIM
5QTZ
5QU0
5USQ
6B8Y
6MAC
8YHF
8YHL
9B9F
9F6X
9FK5
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
SMAD Binding
Regulation Of Primary Metabolic Process
I-SMAD Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Transforming Growth Factor Beta Receptor Activity, Type I
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Protein Serine/threonine Kinase Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Heteromeric SMAD Protein Complex
Activin Receptor Signaling Pathway
Endosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-containing Complex
BMP Signaling Pathway
Endothelial Cell Activation
Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of RNA Biosynthetic Process
Regulation Of Protein Catabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Catabolic Process
Homomeric SMAD Protein Complex
Regulation Of Protein Metabolic Process
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Communication
Regulation Of RNA Metabolic Process
Positive Regulation Of Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Proteolysis
Response To Growth Factor
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Signal Transduction
Osteoblast Differentiation
Positive Regulation Of Protein Metabolic Process
Activin Responsive Factor Complex
Regulation Of Developmental Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Signal Transduction
Protein Serine/threonine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Type I Transforming Growth Factor Beta Receptor Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of SMAD Protein Signal Transduction
SMAD Binding
Cytosol
Kinase Activity
Response To Growth Factor
GTPase Activity
Cell Surface Receptor Signaling Pathway
Protein Modification Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Epithelial To Mesenchymal Transition
I-SMAD Binding
Modification-dependent Protein Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Epithelial To Mesenchymal Transition
GTP Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Heteromeric SMAD Protein Complex
Transferase Activity
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Binding
SMAD Protein Signal Transduction
Post-translational Protein Modification
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