PTHLH

Gene Name		parathyroid hormone-like hormone
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Hormone Activity Peptide Hormone Receptor Binding
	Biological Process	Skeletal System Development Endochondral Ossification Osteoblast Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Endoderm Development Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Protein Processing Positive Regulation Of CAMP Biosynthetic Process Epithelial Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Surfactant Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity CAMP Metabolic Process Lung Alveolus Development Mammary Gland Bud Elongation Nipple Sheath Formation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Breast size ( 22747683)
Protein-protein Interactions		6 interactors: ARRB1 CDK2 IL6 KLK3 KPNB1 PTH1R
Entrez ID		5744
HPRD ID		01348
Ensembl ID		ENSG00000087494
Uniprot IDs		P12272 Q53XY9
PDB IDs		1BZG 1ET3 1M5N 3FFD 3H3G
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Acute Inflammatory Response Bone Remodeling Regulation Of Protein Processing Positive Regulation Of DNA Replication Regulation Of Acute Inflammatory Response Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Glucagon Secretion Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Tissue Remodeling Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Factor XII Activation Hepatic Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of Chemokine Biosynthetic Process Neutrophil Apoptotic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Protein Secretion Response To Reactive Oxygen Species Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity T-helper 17 Cell Differentiation Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death
Tagcloud ?		2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand