PTHLH and KPNB1

Number of citations of the paper that reports this interaction (PMID 12504010)
35

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PTHLH	KPNB1
Gene Name		parathyroid hormone-like hormone	karyopherin (importin) beta 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	Hormone Activity Peptide Hormone Receptor Binding	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding
	Biological Process	Skeletal System Development Endochondral Ossification Osteoblast Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Endoderm Development Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Protein Processing Positive Regulation Of CAMP Biosynthetic Process Epithelial Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Surfactant Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity CAMP Metabolic Process Lung Alveolus Development Mammary Gland Bud Elongation Nipple Sheath Formation	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Breast size ( 22747683)	Multiple sclerosis ( 22190364)
Protein-Protein Interactions		6 interactors: ARRB1 CDK2 IL6 KLK3 KPNB1 PTH1R	59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP
Entrez ID		5744	3837
HPRD ID		01348	04114
Ensembl ID		ENSG00000087494
Uniprot IDs		P12272 Q53XY9	B7Z752 B7ZAV6 Q14974
PDB IDs		1BZG 1ET3 1M5N 3FFD 3H3G	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Acute Inflammatory Response Bone Remodeling Regulation Of Protein Processing Positive Regulation Of DNA Replication Regulation Of Acute Inflammatory Response Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Glucagon Secretion Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Tissue Remodeling Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Factor XII Activation Hepatic Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of Chemokine Biosynthetic Process Neutrophil Apoptotic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Protein Secretion Response To Reactive Oxygen Species Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity T-helper 17 Cell Differentiation Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death	Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance
Tagcloud ?		2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Difference) ?		2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Intersection) ?