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ZBTB43 and PSMD3
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
ZBTB43
PSMD3
Gene Name
zinc finger and BTB domain containing 43
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Metal Ion Binding
Enzyme Regulator Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Protein Catabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Neutrophil count (
20172861
)
White blood cell count (
20139978
21738480
)
White blood cell types (
21738478
)
Protein-Protein Interactions
19 interactors:
AEN
AP1M1
ARR3
ARRB1
BDP1
DIP2A
FAM161A
LMO1
LMO3
LMO4
LNX1
MCM10
MORF4L2
PSMD3
SYT6
TCEB3B
TRAF2
ZBTB24
ZNF417
4 interactors:
BLM
CEP44
SHFM1
ZBTB43
Entrez ID
23099
5709
HPRD ID
08346
10170
Ensembl ID
ENSG00000169155
ENSG00000108344
Uniprot IDs
O43298
O43242
PDB IDs
2CSH
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Glucocorticoid Receptor Signaling Pathway
Regulation Of Metabolic Process
Protein Ubiquitination
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Positive Regulation Of Protein Binding
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Post-Golgi Vesicle-mediated Transport
Acrosomal Vesicle Exocytosis
Negative Regulation Of Protein Ubiquitination
Signal Transduction By P53 Class Mediator
Positive Regulation Of Binding
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Double-strand Break Repair
DNA Recombination
Cellular Response To Camptothecin
Cellular Response To Hydroxyurea
Response To Camptothecin
Negative Regulation Of Mitotic Recombination
Regulation Of Mitotic Recombination
Negative Regulation Of Thymocyte Apoptotic Process
Replication Fork Protection
DNA Double-strand Break Processing
DNA Strand Renaturation
Positive Regulation Of Alpha-beta T Cell Proliferation
DNA Repair
Replication Fork Processing
Mitotic G2 DNA Damage Checkpoint
Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of DNA Recombination
Negative Regulation Of T Cell Apoptotic Process
Cellular Response To DNA Damage Stimulus
Response To X-ray
G2 DNA Damage Checkpoint
DNA Catabolic Process, Exonucleolytic
Cellular Response To Alkaloid
Regulation Of T Cell Apoptotic Process
DNA Metabolic Process
Negative Regulation Of DNA Replication
Negative Regulation Of Leukocyte Apoptotic Process
Nucleobase-containing Compound Metabolic Process
Cellular Response To Ionizing Radiation
Alpha-beta T Cell Differentiation
Regulation Of Lymphocyte Apoptotic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of DNA Recombination
Alpha-beta T Cell Activation
Cellular Nitrogen Compound Metabolic Process
DNA Duplex Unwinding
Telomere Maintenance
DNA Geometric Change
Negative Regulation Of Cell Division
Positive Regulation Of T Cell Proliferation
Cellular Response To Stress
Mitotic DNA Damage Checkpoint
Negative Regulation Of DNA Metabolic Process
Mitotic DNA Integrity Checkpoint
Nitrogen Compound Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA-dependent DNA Replication
Tagcloud
?
annotations
atlas
canx
cascade
combinatorial
constrained
dataset
distinguishing
dnm1
dysregulated
exhaustively
exhibiting
gbm
glioblastoma
hspa9
label
mapk1
multiforme
outlines
ppi
ppis
programmed
proteomics
signature
signatures
subnetwork
survivor
tcga
translatable
Tagcloud (Difference)
?
annotations
atlas
canx
cascade
combinatorial
constrained
dataset
distinguishing
dnm1
dysregulated
exhaustively
exhibiting
gbm
glioblastoma
hspa9
label
mapk1
multiforme
outlines
ppi
ppis
programmed
proteomics
signature
signatures
subnetwork
survivor
tcga
translatable
Tagcloud (Intersection)
?