ZBTB43 and AEN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZBTB43	AEN
Description		zinc finger and BTB domain containing 43	apoptosis enhancing nuclease
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase III General Transcription Initiation Factor Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	DNA Metabolic Process RNA Processing Apoptotic Process DNA Damage Response Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Eyebrow thickness ( 26926045)	Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		28 interacting genes: AEN AP1M1 ARR3 ARRB1 BDP1 CCDC13 CDKL3 CIB3 DDX6 DIP2A DSCAM ELOA2 FAM161A LMO1 LMO3 LMO4 LNX1 MCM10 MORF4L1 MORF4L2 PSMD3 SYT6 TCEA2 TRAF2 ZBTB24 ZNF250 ZNF417 ZNF587	36 interacting genes: EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473
Entrez ID		23099	64782
HPRD ID		08346	08573
Ensembl ID		ENSG00000169155	ENSG00000181026
Uniprot IDs		O43298	Q8WTP8
PDB IDs		2CSH 8YMZ
Enriched GO Terms of Interacting Partners?			Keratin Filament Intermediate Filament Identical Protein Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Zinc Ion Binding Regulation Of RNA Splicing Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Macromolecule Biosynthetic Process
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