GIMAP5 and DKK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIMAP5	DKK4
Description		GTPase, IMAP family member 5	dickkopf Wnt signaling pathway inhibitor 4
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process		Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Hair Follicle Placode Formation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS
Interacting Genes		68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27	3 interacting genes: GIMAP5 ITGAM TSPO2
Entrez ID		55340	27121
HPRD ID		16280	05660
Ensembl ID		ENSG00000196329	ENSG00000104371
Uniprot IDs		A0A090N8P9 Q96F15	Q9UBT3
PDB IDs		6Z3E	5O57
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly	ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB4 Signaling Pathway Integrin Binding Endocardial Cell Differentiation Nickel Cation Binding Integrin AlphaM-beta2 Complex Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Ectodermal Cell Differentiation 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Protein Autophosphorylation ERBB4-ERBB4 Signaling Pathway Regulation Of Neutrophil Degranulation Response To Gram-positive Bacterium Enucleate Erythrocyte Differentiation Activation Of Protein Kinase B Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Synapse Pruning Cardiac Muscle Cell Myoblast Differentiation Complement Component C3b Binding Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Complement Receptor Mediated Signaling Pathway Protein Tyrosine Kinase Activator Activity Stem Cell Development Mammary Gland Development Positive Regulation Of Heart Growth Endothelial Cell Differentiation Heart Trabecula Morphogenesis Cardiac Muscle Cell Differentiation Myoblast Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peripheral Nervous System Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Neural Crest Cell Development ERBB2 Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Secretion
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