GIMAP5 and AQP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIMAP5	AQP3
Description		GTPase, IMAP family member 5	aquaporin 3 (Gill blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Channel Activity Identical Protein Binding
	Biological Process		Positive Regulation Of Immune System Process Response To Ischemia Renal Water Homeostasis Water Transport Glycerol Transmembrane Transport Urea Transport Response To Retinoic Acid Response To Vitamin D Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hypoxia Urea Transmembrane Transport
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			Bisacodyl Sennosides
Diseases
GWAS			Lung adenocarcinoma ( 28604730 31326317) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27	28 interacting genes: C14orf180 CD79A ERG28 ERGIC3 EVI2B FAM209A GIMAP5 GPR152 GPX8 HIBADH LEUTX LMNA MFF MGST3 MRM1 MUC1 OLFM4 PLD2 PLP2 SAR1A SGPL1 SSMEM1 STX1A TMEM107 TMEM42 TMEM86A TNF VASN
Entrez ID		55340	360
HPRD ID		16280	08970
Ensembl ID		ENSG00000196329	ENSG00000165272
Uniprot IDs		A0A090N8P9 Q96F15	A0A2R8Y2R4 B4E034 Q92482
PDB IDs		6Z3E
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly	Membrane
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