GIMAP5 and GJB3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GIMAP5	GJB3
Name		GTPase, IMAP family member 5	gap junction protein beta 3
Structure			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane	Cytoplasm Plasma Membrane Cell-cell Junction Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Gap Junction Channel Activity Protein Binding
	Biological Process	None	Placenta Development Cell Communication Cell-cell Signaling Transmembrane Transport
Pathways		None	Gap junction assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Diseases		None	Deafness, autosomal recessive Erythrokeratodermia variabilis Deafness, autosomal dominant
GWAS		No GWAS studies recorded	Intraocular pressure ( 30591961 ) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883 )
Novel Interactors		1 novel interactors: CHPF2	1 novel interactors: TUBD1
Interacting Genes		68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27	15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1
Entrez ID		55340	2707
HPRD ID		16280	04505
Ensembl ID		ENSG00000196329	ENSG00000188910
Uniprot IDs		A0A090N8P9 Q96F15	O75712
PDB IDs		6Z3E	Not available
GO Terms Enriched among Interactors		Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly	None