GIMAP5 and TNFRSF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GIMAP5	TNFRSF19
Description		GTPase, IMAP family member 5	TNF receptor superfamily member 19
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process		Hair Follicle Development Apoptotic Process JNK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS			Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Diabetic kidney disease ( 26305897) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145 26545403) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27	9 interacting genes: GIMAP5 MTURN SGTA SGTB TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		55340	55504
HPRD ID		16280	05838
Ensembl ID		ENSG00000196329	ENSG00000127863
Uniprot IDs		A0A090N8P9 Q96F15	Q9NS68
PDB IDs		6Z3E
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Signaling Adaptor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity TRC Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Identical Protein Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of JUN Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of JNK Cascade Protein Targeting To ER Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Endosome Membrane MRNA Transcription TORC2 Complex Disassembly Regulation Of Interleukin-2 Production Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAP Kinase Activity MRNA Stabilization Regulation Of Apoptotic Process
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