LTBR and DIABLO

Number of citations of the paper that reports this interaction (PubMedID 12571250)
0

Data Source:
HPRD (in vitro, in vivo)

		LTBR	DIABLO
Description		lymphotoxin beta receptor	diablo IAP-binding mitochondrial protein
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Myeloid Dendritic Cell Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Hematopoietic Or Lymphoid Organ Development Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Aspartate aminotransferase levels ( 33547301) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 28928442 27182965) White blood cell count ( 32888494)	A body shape index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	45 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CDC34 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HSFX1 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBC UBE2K UFM1 XIAP ZNF746
Entrez ID		4055	56616
HPRD ID		02988	05560
Ensembl ID		ENSG00000111321	ENSG00000184047
Uniprot IDs		P36941	A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs		1RF3 4MXW	1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6 8ATO 8AUW 8E2I 8E2J
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Adaptor Activity Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Activity Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Apoptotic Process Zinc Ion Binding Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Programmed Necrotic Cell Death Signaling Cell Communication Response To Other Organism Positive Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Regulation Of JNK Cascade	Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cell Death Apoptotic Process Programmed Cell Death Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Cellular Response To Interferon-beta Macromolecule Catabolic Process Negative Regulation Of Apoptotic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Programmed Cell Death Response To Interferon-beta Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Signal Recognition Particle Binding Peptidase Inhibitor Activity Post-translational Protein Modification Ubiquitin Protein Ligase Activity CD40 Receptor Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Modification Process Identical Protein Binding Canonical NF-kappaB Signal Transduction Organophosphate Ester Transport Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Polyubiquitination Response To Hypoxia Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Very-low-density Lipoprotein Particle Negative Regulation Of Programmed Necrotic Cell Death Response To Decreased Oxygen Levels Protein Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleotide Transmembrane Transport
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